Carmofur‐Induced Organic Mental Disorders

Toshihito Suzuki, Junzo Koizumi*, Kaoru Uchida, Hiroyasu Shiraishi, Masashi Hori

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Summary: Organic mental disorder was observed in a 29‐year‐old female in the prognostic period after the onset of carniofur‐induced lenkoencephalopathy. Symptoms such as euphoria, emotional lability and puerile attitude noted in the patient were diagnosed as organic personality syndrome according to the criteria defined in the DSM‐HI‐R. It is referred to as a frontal lobe syndrome. Brain CT revealed a periventricular low density area in the frontal white matter and moderate dilatation of the lateral ventricles especially at the bilateral anterior horns. Consequently, carmofur‐induced leukoencepha‐lopathy may uncommonly result in organic personality syndrome in the residual state. It may be attributed to the structural damage to the frontal lobe.

Original languageEnglish
Pages (from-to)723-727
Number of pages5
JournalPsychiatry and Clinical Neurosciences
Issue number4
Publication statusPublished - 1990 Dec
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health


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