Ca2+ signaling regulated by an ATP-dependent autocrine mechanism in astrocytes

H. Shiga, T. Tojima, E. Ito*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Although the mechanisms of Ca2+ wave propagation in astrocytes induced by mechanical stimulation have been well studied, it is still not known how the [Ca2+]i increases in the stimulated cells. Here, we have analyzed the mechanisms of [Ca2+]i increase in single, isolated astrocytes. Our results showed that there was an autocrine mechanism of Ca2+ regulation mediated by ATP in mechanically stimulated astrocytes. This autocrine mechanism induced the activation of phospholipase C via a G-protein, resulting in Ca2+ release from intracellular Ca2+ stores. A second pathway mediating a [Ca2+]i increase was via a Ca2+ influx from the extracellular space, which, interestingly, suppressed an intracellular Ca2+ oscillation. These two different Ca2+ cascades are involved in signal transduction and may function separately during intercellular communication.

Original languageEnglish
Pages (from-to)2619-2622
Number of pages4
Issue number12
Publication statusPublished - 2001 Aug 28
Externally publishedYes


  • Calcium oscillation
  • Phospholipase C
  • Purine receptor

ASJC Scopus subject areas

  • Neuroscience(all)


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