Catalytic asymmetric intramolecular cyclopropanation of α-diazo-α-phosphoryl acetate

Saori Inoue, Kotaro Nagatani, Yunosuke Hoshino, Haruka Tezuka, Nasahisa Nakada

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)


    The catalytic asymmetric intramolecular cyclopropanation (CAIMCP) of α-diazo-α-diphenylphosphoryl acetate has been investigated. The maximum ee of the CAIMCP was 91% and the absolute configuration of the two products was successfully determined. Our previously reported model to explain the enantiofacial selectivity of the reacting alkene was successfully applied to rationalize the enantioselectivity of the CAIMCP.

    Original languageEnglish
    Pages (from-to)541-553
    Number of pages13
    Issue number3
    Publication statusPublished - 2017

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Pharmacology
    • Organic Chemistry


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