@article{3fb6fbf49b3c472598b8aade1fa43a08,
title = "Catenulisporolides, Glycosylated Triene Macrolides from the Chemically Underexploited Actinomycete Catenulispora Species",
abstract = "New glycosylated 26-membered triene macrolides catenulisporolides, the first polyketide metabolites from Catenulispora species, were obtained by targeting slow-forming colonies on selection agar plates and applying long-term cultivation. Their structures, including the full stereochemistry, were defined by comprehensive spectroscopic and chemical methods and confirmed by bioinformatics analysis. Analysis of the genome sequence revealed the responsible biosynthetic gene cluster spanning ∼160 kbp, and feeding experiments with isotope-labeled precursors showed that isovaleric acid acts as a rare starter unit. Catenulisporolides exhibited antimalarial activities against resistant strains of Plasmodium falciparum, and enhanced activity was observed in semisynthetic derivatives.",
author = "Sangkeun Son and Hong, {Young Soo} and Yushi Futamura and Mina Jang and Lee, {Jae Kyoung} and Heo, {Kyung Taek} and Ko, {Sung Kyun} and Lee, {Jung Sook} and Shunji Takahashi and Hiroyuki Osada and Jang, {Jae Hyuk} and Ahn, {Jong Seog}",
note = "Funding Information: This work was supported by an International Joint Research Project (ASIA-16-011) of the NST (National Research Council of Science & Technology), Young Researcher Program (NRF-2017R1C1B2002602) of the NRF (National Research Foundation of Korea), and the KRIBB Research Initiative Program funded by the Ministry of Science ICT (MSIT) of the Republic of Korea. We also thank the Korea Basic Science Institute, Ochang, Korea, for providing the NMR and HRESIMS data. Funding Information: The authors wish to thank Harumi Aono (RIKEN CSRS) for the biological activity tests. This work was supported by an International Joint Research Project (ASIA-16-011) of the NST (National Research Council of Science & Technology), Young Researcher Program (NRF-2017R1C1B2002602) of the NRF (National Research Foundation of Korea), and the KRIBB Research Initiative Program funded by the Ministry of Science ICT (MSIT) of the Republic of Korea. We also thank the Korea Basic Science Institute, Ochang, Korea, for providing the NMR and HRESIMS data. Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = nov,
day = "16",
doi = "10.1021/acs.orglett.8b03160",
language = "English",
volume = "20",
pages = "7234--7238",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "22",
}