Cdk5/p35 regulates neuronal migration

Toshio Ohshima*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Neurons migrate from proliferative zone to their final position during brain development. Cyclin-dependent kinase 5 (Cdk5) plays an important role in neuronal migration to establish a proper structure of the brain. Analyses of Cdk5/p35-deficient mice have provided the knowledge about the role of Cdk5/p35 in neuronal migration. Over the past years, migration-related substrates of Cdk5 have been identified. Imaging analyses of neuronal migration of Cdk5/p35-deficient neurons have begun to elucidate how proper phosphorylations of these proteins by Cdk5/p35 are required for the regulation of cytoskeletal dynamics and cellular adhesion during neuronal migration.

Original languageEnglish
Title of host publicationCyclin Dependent Kinase 5 (Cdk5)
PublisherSpringer US
Number of pages8
ISBN (Electronic)9780387788876
ISBN (Print)9780387788869
Publication statusPublished - 2008 Jan 1

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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