Abstract
Neurons migrate from proliferative zone to their final position during brain development. Cyclin-dependent kinase 5 (Cdk5) plays an important role in neuronal migration to establish a proper structure of the brain. Analyses of Cdk5/p35-deficient mice have provided the knowledge about the role of Cdk5/p35 in neuronal migration. Over the past years, migration-related substrates of Cdk5 have been identified. Imaging analyses of neuronal migration of Cdk5/p35-deficient neurons have begun to elucidate how proper phosphorylations of these proteins by Cdk5/p35 are required for the regulation of cytoskeletal dynamics and cellular adhesion during neuronal migration.
| Original language | English |
|---|---|
| Title of host publication | Cyclin Dependent Kinase 5 (Cdk5) |
| Publisher | Springer US |
| Pages | 1-8 |
| Number of pages | 8 |
| ISBN (Electronic) | 9780387788876 |
| ISBN (Print) | 9780387788869 |
| DOIs | |
| Publication status | Published - 2008 |
ASJC Scopus subject areas
- General Medicine
- General Neuroscience