Cerebral and renal hemodynamics: similarities, differences, and associations with chronic kidney disease and aortic hemodynamics

Keisei Kosaki, Takashi Tarumi, Shoya Mori, Masahiro Matsui, Jun Sugawara, Takeshi Sugaya, Makoto Kuro-o, Chie Saito, Kunihiro Yamagata, Koichiro Oka, Seiji Maeda*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Elevated arterial pulsatility is a common risk factor for cerebrovascular disease and chronic kidney disease (CKD), which suggests that the brain and kidneys may have similar hemodynamic profiles. The objectives of this study were twofold: 1) to compare and contrast the cerebral and renal blood flow parameters in adults without CKD (hereafter, non-CKD adults) and CKD patients and 2) to determine the common predictor(s) of cerebral and renal hemodynamics among pressure pulsatility and several cardiovascular risk factors. In 110 non-CKD adults and 66 CKD patients, cerebral and renal blood flow velocity (BFV) were measured by transcranial Doppler and Duplex ultrasonography, respectively. Pulsatile hemodynamics were assessed by the pulsatility (PI) and resistive (RI) indices. Aortic pulse pressure was measured by tonometry. Compared with non-CKD adults, CKD patients showed greater pulsatility of the BFV (i.e., systolic minus diastolic BFV), PI, and RI in the kidneys but not the brain. However, the cerebral and renal PI and RI values were strongly correlated in both non-CKD adults (both PI and RI values: rs = 0.695) and CKD patients (both PI and RI values: rs = 0.640) (all P < 0.001). Multiple linear regression analysis further demonstrated that the cerebral and renal PI and RI associations remained significant after adjustment for potential covariates (e.g., age, sex, the presence of CKD). The aortic pulse pressure was a significant predictor for both cerebral and renal PI and RI values. Collectively, our findings suggest that CKD patients have higher renal flow pulsatility, which is strongly and independently associated with cerebral flow pulsatility and aortic hemodynamics.

Original languageEnglish
Pages (from-to)1363-1372
Number of pages10
JournalHypertension Research
Issue number8
Publication statusPublished - 2022 Aug


  • Aortic pulse pressure
  • Cerebral blood flow
  • Pulsatility index
  • Renal blood flow
  • Resistive index

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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