Cerebral glucose metabolism associated with a fear network in panic disorder

Yojiro Sakai; Hiroaki Kumano; Masami Nishikawa; Yuji Sakano; Hisanobu Kaiya; Etsuko Imabayashi; Takashi Ohnishi; Hiroshi Matsuda; Asako Yasuda; Atsushi Sato; Mirko Diksic; Tomifusa Kuboki

doi:10.1097/00001756-200506210-00010

Cerebral glucose metabolism associated with a fear network in panic disorder

Yojiro Sakai^*, Hiroaki Kumano, Masami Nishikawa, Yuji Sakano, Hisanobu Kaiya, Etsuko Imabayashi, Takashi Ohnishi, Hiroshi Matsuda, Asako Yasuda, Atsushi Sato, Mirko Diksic, Tomifusa Kuboki

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

153 Citations (Scopus)

Abstract

The present study was performed to assess cerebral glucose metabolism in patients with panic disorder using positron emission tomography. ¹⁸F-fluorodeoxyglucose positron emission tomography with voxel-based analysis was used to compare regional brain glucose utilization in 12 nonmedicated panic disorder patients, without their experiencing panic attacks during positron emission tomography acquisition, with that in 22 healthy controls. Panic disorder patients showed appreciably high state anxiety before scanning, and exhibited significantly higher levels of glucose uptake in the bilateral amygdala, hippocampus, and thalamus, and in the midbrain, caudal pons, medulla, and cerebellum than controls. These results provided the first functional neuroimaging support in human patients for the neuroanatomical hypothesis of panic disorder focusing on the amygdala-based fear network.

Original language	English
Pages (from-to)	927-931
Number of pages	5
Journal	NeuroReport
Volume	16
Issue number	9
DOIs	https://doi.org/10.1097/00001756-200506210-00010
Publication status	Published - 2005 Jun 21
Externally published	Yes

Keywords

Amygdala
Anticipatory anxiety
Fear network
Panic attack
Panic disorder
Positron emission tomography
Regional brain glucose metabolism

ASJC Scopus subject areas

Neuroscience(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/00001756-200506210-00010

Cite this

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title = "Cerebral glucose metabolism associated with a fear network in panic disorder",

abstract = "The present study was performed to assess cerebral glucose metabolism in patients with panic disorder using positron emission tomography. 18F-fluorodeoxyglucose positron emission tomography with voxel-based analysis was used to compare regional brain glucose utilization in 12 nonmedicated panic disorder patients, without their experiencing panic attacks during positron emission tomography acquisition, with that in 22 healthy controls. Panic disorder patients showed appreciably high state anxiety before scanning, and exhibited significantly higher levels of glucose uptake in the bilateral amygdala, hippocampus, and thalamus, and in the midbrain, caudal pons, medulla, and cerebellum than controls. These results provided the first functional neuroimaging support in human patients for the neuroanatomical hypothesis of panic disorder focusing on the amygdala-based fear network.",

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AU - Sakai, Yojiro

AU - Kumano, Hiroaki

AU - Nishikawa, Masami

AU - Sakano, Yuji

AU - Kaiya, Hisanobu

AU - Imabayashi, Etsuko

AU - Ohnishi, Takashi

AU - Matsuda, Hiroshi

AU - Yasuda, Asako

AU - Sato, Atsushi

AU - Diksic, Mirko

AU - Kuboki, Tomifusa

PY - 2005/6/21

Y1 - 2005/6/21

N2 - The present study was performed to assess cerebral glucose metabolism in patients with panic disorder using positron emission tomography. 18F-fluorodeoxyglucose positron emission tomography with voxel-based analysis was used to compare regional brain glucose utilization in 12 nonmedicated panic disorder patients, without their experiencing panic attacks during positron emission tomography acquisition, with that in 22 healthy controls. Panic disorder patients showed appreciably high state anxiety before scanning, and exhibited significantly higher levels of glucose uptake in the bilateral amygdala, hippocampus, and thalamus, and in the midbrain, caudal pons, medulla, and cerebellum than controls. These results provided the first functional neuroimaging support in human patients for the neuroanatomical hypothesis of panic disorder focusing on the amygdala-based fear network.

AB - The present study was performed to assess cerebral glucose metabolism in patients with panic disorder using positron emission tomography. 18F-fluorodeoxyglucose positron emission tomography with voxel-based analysis was used to compare regional brain glucose utilization in 12 nonmedicated panic disorder patients, without their experiencing panic attacks during positron emission tomography acquisition, with that in 22 healthy controls. Panic disorder patients showed appreciably high state anxiety before scanning, and exhibited significantly higher levels of glucose uptake in the bilateral amygdala, hippocampus, and thalamus, and in the midbrain, caudal pons, medulla, and cerebellum than controls. These results provided the first functional neuroimaging support in human patients for the neuroanatomical hypothesis of panic disorder focusing on the amygdala-based fear network.

KW - Amygdala

KW - Anticipatory anxiety

KW - Fear network

KW - Panic attack

KW - Panic disorder

KW - Positron emission tomography

KW - Regional brain glucose metabolism

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Cerebral glucose metabolism associated with a fear network in panic disorder

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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