Changes in amygdaloid afterdischarges and kindling effect following olfactory bulbectomy in the rat

Shigenori Watanabe; Hiroshi Nakanishi; Shigenobu Shibata; Showa Ueki

doi:10.1016/0031-9384(82)90052-X

Changes in amygdaloid afterdischarges and kindling effect following olfactory bulbectomy in the rat

Shigenori Watanabe^*, Hiroshi Nakanishi, Shigenobu Shibata, Showa Ueki

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Changes in the thresholds for afterdischarges and the formation of kindling effect in the medial amygdala following olfactory bulbectomy were investigated in the rat with chronic electrode implants. The threshold for afterdischarges in the amygdala of the olfactory bulbectomized rat (OB rat) was significantly decreased on day 4 after olfactory bulbectomy, however, no significant difference was found between OB and sham operated rats on days 7, 14 and 21 since the threshold in the sham group was also decreased at these periods after the surgery. The formation of kindling effect was remarkably accelerated in the OB rats. In this case, the number of days required to reach the stage 1 (Racine's classification) was significantly shortened. These results suggest that the activity of the medial amygdaloid nucleus is increased following olfactory bulbectomy.

Original language	English
Pages (from-to)	687-692
Number of pages	6
Journal	Physiology and Behavior
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/0031-9384(82)90052-X
Publication status	Published - 1982 Apr
Externally published	Yes

Keywords

Afterdischarges
Amygdala
Kindling effect
Muricide
Olfactory bulbectomy
Rat

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

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10.1016/0031-9384(82)90052-X

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title = "Changes in amygdaloid afterdischarges and kindling effect following olfactory bulbectomy in the rat",

abstract = "Changes in the thresholds for afterdischarges and the formation of kindling effect in the medial amygdala following olfactory bulbectomy were investigated in the rat with chronic electrode implants. The threshold for afterdischarges in the amygdala of the olfactory bulbectomized rat (OB rat) was significantly decreased on day 4 after olfactory bulbectomy, however, no significant difference was found between OB and sham operated rats on days 7, 14 and 21 since the threshold in the sham group was also decreased at these periods after the surgery. The formation of kindling effect was remarkably accelerated in the OB rats. In this case, the number of days required to reach the stage 1 (Racine's classification) was significantly shortened. These results suggest that the activity of the medial amygdaloid nucleus is increased following olfactory bulbectomy.",

keywords = "Afterdischarges, Amygdala, Kindling effect, Muricide, Olfactory bulbectomy, Rat",

author = "Shigenori Watanabe and Hiroshi Nakanishi and Shigenobu Shibata and Showa Ueki",

note = "Funding Information: This study was supported by Grant-in-Aid for Scientific Research (C-56570080) from the Ministry of Education, Science and Culture of Japan.",

year = "1982",

month = apr,

doi = "10.1016/0031-9384(82)90052-X",

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journal = "Physiology and Behavior",

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T1 - Changes in amygdaloid afterdischarges and kindling effect following olfactory bulbectomy in the rat

AU - Watanabe, Shigenori

AU - Nakanishi, Hiroshi

AU - Shibata, Shigenobu

AU - Ueki, Showa

N1 - Funding Information: This study was supported by Grant-in-Aid for Scientific Research (C-56570080) from the Ministry of Education, Science and Culture of Japan.

PY - 1982/4

Y1 - 1982/4

N2 - Changes in the thresholds for afterdischarges and the formation of kindling effect in the medial amygdala following olfactory bulbectomy were investigated in the rat with chronic electrode implants. The threshold for afterdischarges in the amygdala of the olfactory bulbectomized rat (OB rat) was significantly decreased on day 4 after olfactory bulbectomy, however, no significant difference was found between OB and sham operated rats on days 7, 14 and 21 since the threshold in the sham group was also decreased at these periods after the surgery. The formation of kindling effect was remarkably accelerated in the OB rats. In this case, the number of days required to reach the stage 1 (Racine's classification) was significantly shortened. These results suggest that the activity of the medial amygdaloid nucleus is increased following olfactory bulbectomy.

AB - Changes in the thresholds for afterdischarges and the formation of kindling effect in the medial amygdala following olfactory bulbectomy were investigated in the rat with chronic electrode implants. The threshold for afterdischarges in the amygdala of the olfactory bulbectomized rat (OB rat) was significantly decreased on day 4 after olfactory bulbectomy, however, no significant difference was found between OB and sham operated rats on days 7, 14 and 21 since the threshold in the sham group was also decreased at these periods after the surgery. The formation of kindling effect was remarkably accelerated in the OB rats. In this case, the number of days required to reach the stage 1 (Racine's classification) was significantly shortened. These results suggest that the activity of the medial amygdaloid nucleus is increased following olfactory bulbectomy.

KW - Afterdischarges

KW - Amygdala

KW - Kindling effect

KW - Muricide

KW - Olfactory bulbectomy

KW - Rat

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Changes in amygdaloid afterdischarges and kindling effect following olfactory bulbectomy in the rat

Abstract

Keywords

ASJC Scopus subject areas

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