Changes in heart rate with refeeding in anorexia nervosa: A pilot study

Nahoko (Miyasaka) Yoshida*, Kazuhiro Yoshiuchi, Hiroaki Kumano, Tadashi Sasaki, Tomifusa Kuboki

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Objective: To find differences in heart rate before and after refeeding and to identify which parameters of autonomic activity and endocrine function are associated with these differences. Methods: Before and after the start of refeeding, body weight, RR interval (RRI), heart rate variability, endocrine function, and energy expenditure were measured in nine female anorexia nervosa patients. Results: After short-term refeeding, mean daytime heart rate rose from 54.9 to 69.4 bpm (P<.05). The changes in sympathetic activity were correlated negatively with the changes in RRI (r=-.933, P<.001). Urine C-peptide, IGF-1, and fT3 increased significantly, and norepinephrine tended to increase. Conclusion: We demonstrated that autonomic nervous activity was relevant to changes in heart rate during refeeding, and it is speculated that the increases in insulin secretion, thyroid function, and IGF-1 were responsible for the mechanisms.

Original languageEnglish
Pages (from-to)571-575
Number of pages5
JournalJournal of Psychosomatic Research
Issue number4
Publication statusPublished - 2006 Oct 1
Externally publishedYes


  • Anorexia nervosa
  • Heart rate
  • Parasympathetic activity
  • Refeeding
  • Sympathetic nervous activity

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


Dive into the research topics of 'Changes in heart rate with refeeding in anorexia nervosa: A pilot study'. Together they form a unique fingerprint.

Cite this