Characterization of poly(N-isopropylacrylamide) gel grafted polydimethylsiloxane as temperature-responsive cell culture substrate

Yoshikatsu Akiyama; Miki Matsuyama; Naoya Takeda; Masayuki Yamato; Teruo Okano

doi:10.1109/MHS.2016.7824169

Characterization of poly(N-isopropylacrylamide) gel grafted polydimethylsiloxane as temperature-responsive cell culture substrate

Yoshikatsu Akiyama^*, Miki Matsuyama, Naoya Takeda, Masayuki Yamato, Teruo Okano

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Poly(N-isopropylacrylamide) (PIPAAm) hydrogel modified poly(dimethylsiloxane) (PDMS) surface (PIPAAm-PDMS) was prepared as a new temperature-responsive cell culture surface by using electron beam (EB) irradiation method. PIPAAm-PDMS surface properties at unstretched and stretched states were characterized by using various analytical method. As the result, we found that PIPAAm-PDMS surface properties as well as thickness of the grafted PIPAAm gel were altered by applied uniaxial mechanical stretching stress. The mechanical stress can affect the degree of hydration of grafted PIPAAm chains.

Original language	English
Title of host publication	2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781509027842
DOIs	https://doi.org/10.1109/MHS.2016.7824169
Publication status	Published - 2017 Jan 18
Externally published	Yes
Event	27th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016 - Nagoya, Japan Duration: 2016 Nov 28 → 2016 Nov 30

Other

Other	27th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016
Country/Territory	Japan
City	Nagoya
Period	16/11/28 → 16/11/30

ASJC Scopus subject areas

Medicine (miscellaneous)
Biomedical Engineering
Mechanical Engineering
Human-Computer Interaction
Instrumentation
Computer Science Applications
Biotechnology
Artificial Intelligence

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/MHS.2016.7824169

Cite this

Akiyama, Y., Matsuyama, M., Takeda, N., Yamato, M., & Okano, T. (2017). Characterization of poly(N-isopropylacrylamide) gel grafted polydimethylsiloxane as temperature-responsive cell culture substrate. In 2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016 Article 7824169 Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MHS.2016.7824169

Characterization of poly(N-isopropylacrylamide) gel grafted polydimethylsiloxane as temperature-responsive cell culture substrate. / Akiyama, Yoshikatsu; Matsuyama, Miki; Takeda, Naoya et al.
2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016. Institute of Electrical and Electronics Engineers Inc., 2017. 7824169.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Akiyama, Y, Matsuyama, M, Takeda, N, Yamato, M & Okano, T 2017, Characterization of poly(N-isopropylacrylamide) gel grafted polydimethylsiloxane as temperature-responsive cell culture substrate. in 2016 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016., 7824169, Institute of Electrical and Electronics Engineers Inc., 27th International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016, Nagoya, Japan, 16/11/28. https://doi.org/10.1109/MHS.2016.7824169

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title = "Characterization of poly(N-isopropylacrylamide) gel grafted polydimethylsiloxane as temperature-responsive cell culture substrate",

abstract = "Poly(N-isopropylacrylamide) (PIPAAm) hydrogel modified poly(dimethylsiloxane) (PDMS) surface (PIPAAm-PDMS) was prepared as a new temperature-responsive cell culture surface by using electron beam (EB) irradiation method. PIPAAm-PDMS surface properties at unstretched and stretched states were characterized by using various analytical method. As the result, we found that PIPAAm-PDMS surface properties as well as thickness of the grafted PIPAAm gel were altered by applied uniaxial mechanical stretching stress. The mechanical stress can affect the degree of hydration of grafted PIPAAm chains.",

author = "Yoshikatsu Akiyama and Miki Matsuyama and Naoya Takeda and Masayuki Yamato and Teruo Okano",

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AU - Akiyama, Yoshikatsu

AU - Matsuyama, Miki

AU - Takeda, Naoya

AU - Yamato, Masayuki

AU - Okano, Teruo

PY - 2017/1/18

Y1 - 2017/1/18

N2 - Poly(N-isopropylacrylamide) (PIPAAm) hydrogel modified poly(dimethylsiloxane) (PDMS) surface (PIPAAm-PDMS) was prepared as a new temperature-responsive cell culture surface by using electron beam (EB) irradiation method. PIPAAm-PDMS surface properties at unstretched and stretched states were characterized by using various analytical method. As the result, we found that PIPAAm-PDMS surface properties as well as thickness of the grafted PIPAAm gel were altered by applied uniaxial mechanical stretching stress. The mechanical stress can affect the degree of hydration of grafted PIPAAm chains.

AB - Poly(N-isopropylacrylamide) (PIPAAm) hydrogel modified poly(dimethylsiloxane) (PDMS) surface (PIPAAm-PDMS) was prepared as a new temperature-responsive cell culture surface by using electron beam (EB) irradiation method. PIPAAm-PDMS surface properties at unstretched and stretched states were characterized by using various analytical method. As the result, we found that PIPAAm-PDMS surface properties as well as thickness of the grafted PIPAAm gel were altered by applied uniaxial mechanical stretching stress. The mechanical stress can affect the degree of hydration of grafted PIPAAm chains.

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Characterization of poly(N-isopropylacrylamide) gel grafted polydimethylsiloxane as temperature-responsive cell culture substrate

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