Cholecystokinin, motilin and secretin effects on the central nervous system

Shinichiro Ishibashi; Yutaka Oomura; Taiichiro Okajima; Shigenobu Shibata

doi:10.1016/0031-9384(79)90386-X

Cholecystokinin, motilin and secretin effects on the central nervous system

Shinichiro Ishibashi^*, Yutaka Oomura, Taiichiro Okajima, Shigenobu Shibata

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Using multibarreled microelectrode technique, cholecystokinin (CCK), motilin and secretin were applied to neurons in the lateral hypothalamic area, the ventromedial hypothalamic nucleus, the cerebral cortex and the thalamus. These intestinal hormones had little effect on the hypothalamic neurons. It is difficult to say that the intestinal hormones hematogenically affect hypothalamic neurons to regulate feeding behavior. CCK, on the other hand, affected cerebral cortex neurons in most cases. CCK probably has some role in the central nervous system, because it exists in and has electrophysiological effects in the central nervous system.

Original language	English
Pages (from-to)	401-403
Number of pages	3
Journal	Physiology and Behavior
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/0031-9384(79)90386-X
Publication status	Published - 1979 Aug
Externally published	Yes

Keywords

Cholecystokinin
Electroosmotic application
Feeding behavior
Motilin
Secretin

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

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10.1016/0031-9384(79)90386-X

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title = "Cholecystokinin, motilin and secretin effects on the central nervous system",

abstract = "Using multibarreled microelectrode technique, cholecystokinin (CCK), motilin and secretin were applied to neurons in the lateral hypothalamic area, the ventromedial hypothalamic nucleus, the cerebral cortex and the thalamus. These intestinal hormones had little effect on the hypothalamic neurons. It is difficult to say that the intestinal hormones hematogenically affect hypothalamic neurons to regulate feeding behavior. CCK, on the other hand, affected cerebral cortex neurons in most cases. CCK probably has some role in the central nervous system, because it exists in and has electrophysiological effects in the central nervous system.",

keywords = "Cholecystokinin, Electroosmotic application, Feeding behavior, Motilin, Secretin",

author = "Shinichiro Ishibashi and Yutaka Oomura and Taiichiro Okajima and Shigenobu Shibata",

note = "Funding Information: We would like to thank Dr. S. J. Lucania of Squibb Institute of Medical Research for donating CCK octapeptide a~ ProL Yarmih-ara of Shizuoka Phammcological University for donating motilin. This work was partly supported by grants 139017, 221216, 222012, 244021, 187015, and 212110 from the Ministry of Education, Science and Culture.",

year = "1979",

month = aug,

doi = "10.1016/0031-9384(79)90386-X",

language = "English",

volume = "23",

pages = "401--403",

journal = "Physiology and Behavior",

issn = "0031-9384",

publisher = "Elsevier Inc.",

number = "2",

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T1 - Cholecystokinin, motilin and secretin effects on the central nervous system

AU - Ishibashi, Shinichiro

AU - Oomura, Yutaka

AU - Okajima, Taiichiro

AU - Shibata, Shigenobu

N1 - Funding Information: We would like to thank Dr. S. J. Lucania of Squibb Institute of Medical Research for donating CCK octapeptide a~ ProL Yarmih-ara of Shizuoka Phammcological University for donating motilin. This work was partly supported by grants 139017, 221216, 222012, 244021, 187015, and 212110 from the Ministry of Education, Science and Culture.

PY - 1979/8

Y1 - 1979/8

N2 - Using multibarreled microelectrode technique, cholecystokinin (CCK), motilin and secretin were applied to neurons in the lateral hypothalamic area, the ventromedial hypothalamic nucleus, the cerebral cortex and the thalamus. These intestinal hormones had little effect on the hypothalamic neurons. It is difficult to say that the intestinal hormones hematogenically affect hypothalamic neurons to regulate feeding behavior. CCK, on the other hand, affected cerebral cortex neurons in most cases. CCK probably has some role in the central nervous system, because it exists in and has electrophysiological effects in the central nervous system.

AB - Using multibarreled microelectrode technique, cholecystokinin (CCK), motilin and secretin were applied to neurons in the lateral hypothalamic area, the ventromedial hypothalamic nucleus, the cerebral cortex and the thalamus. These intestinal hormones had little effect on the hypothalamic neurons. It is difficult to say that the intestinal hormones hematogenically affect hypothalamic neurons to regulate feeding behavior. CCK, on the other hand, affected cerebral cortex neurons in most cases. CCK probably has some role in the central nervous system, because it exists in and has electrophysiological effects in the central nervous system.

KW - Cholecystokinin

KW - Electroosmotic application

KW - Feeding behavior

KW - Motilin

KW - Secretin

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DO - 10.1016/0031-9384(79)90386-X

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SN - 0031-9384

VL - 23

SP - 401

EP - 403

JO - Physiology and Behavior

JF - Physiology and Behavior

IS - 2

ER -

Cholecystokinin, motilin and secretin effects on the central nervous system

Abstract

Keywords

ASJC Scopus subject areas

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