Cholecystokinin, motilin and secretin effects on the central nervous system

Shinichiro Ishibashi*, Yutaka Oomura, Taiichiro Okajima, Shigenobu Shibata

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Using multibarreled microelectrode technique, cholecystokinin (CCK), motilin and secretin were applied to neurons in the lateral hypothalamic area, the ventromedial hypothalamic nucleus, the cerebral cortex and the thalamus. These intestinal hormones had little effect on the hypothalamic neurons. It is difficult to say that the intestinal hormones hematogenically affect hypothalamic neurons to regulate feeding behavior. CCK, on the other hand, affected cerebral cortex neurons in most cases. CCK probably has some role in the central nervous system, because it exists in and has electrophysiological effects in the central nervous system.

Original languageEnglish
Pages (from-to)401-403
Number of pages3
JournalPhysiology and Behavior
Issue number2
Publication statusPublished - 1979 Aug
Externally publishedYes


  • Cholecystokinin
  • Electroosmotic application
  • Feeding behavior
  • Motilin
  • Secretin

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience


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