Chrono-biology, chrono-pharmacology, and chrono-nutrition

Yu Tahara, Shigenobu Shibata*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

55 Citations (Scopus)


The circadian clock system in mammals drives many physiological processes including the daily rhythms of sleep-wake behavior, hormonal secretion, and metabolism. This system responds to daily environmental changes, such as the light-dark cycle, food intake, and drug administration. In this review, we focus on the central and peripheral circadian clock systems in response to drugs, food, and nutrition. We also discuss the adaptation and anticipation mechanisms of our body with regard to clock system regulation of various kinetic and dynamic pathways, including absorption, distribution, metabolism, and excretion of drugs and nutrients. "Chronopharmacology" and "chrono- nutrition" are likely to become important research fields in chronobiological studies.

Original languageEnglish
Pages (from-to)320-335
Number of pages16
JournalJournal of Pharmacological Sciences
Issue number3
Publication statusPublished - 2014


  • Circadian rhythm
  • Liver
  • Metabolism
  • Obesity
  • Period 2 gene

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology


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