Ciliatamides A-C, bioactive lipopeptides from the deep-sea sponge Aaptos ciliata

Yoichi Nakao; Shizuka Kawatsu; Chikane Okamoto; Masaaki Okamoto; Yoshitsugu Matsumoto; Shigeki Matsunaga; Rob W.M. Van Soest; Nobuhiro Fusetani

doi:10.1021/np8000317

Ciliatamides A-C, bioactive lipopeptides from the deep-sea sponge Aaptos ciliata

Yoichi Nakao^*, Shizuka Kawatsu, Chikane Okamoto, Masaaki Okamoto, Yoshitsugu Matsumoto, Shigeki Matsunaga, Rob W.M. Van Soest, Nobuhiro Fusetani

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Three lipopeptides, ciliatamides A-C (1-3), were isolated from the deep-sea sponge Aaptos ciliata, and their structures were elucidated on the basis of spectroscopic and chemical methods. Ciliatamides A (1) and B (2) were found to be antileishmanial, while 2 also exhibited marginal cytotoxicity to HeLa cells.

Original language	English
Pages (from-to)	469-472
Number of pages	4
Journal	Journal of Natural Products
Volume	71
Issue number	3
DOIs	https://doi.org/10.1021/np8000317
Publication status	Published - 2008 Mar 1

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np8000317

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abstract = "Three lipopeptides, ciliatamides A-C (1-3), were isolated from the deep-sea sponge Aaptos ciliata, and their structures were elucidated on the basis of spectroscopic and chemical methods. Ciliatamides A (1) and B (2) were found to be antileishmanial, while 2 also exhibited marginal cytotoxicity to HeLa cells.",

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AU - Nakao, Yoichi

AU - Kawatsu, Shizuka

AU - Okamoto, Chikane

AU - Okamoto, Masaaki

AU - Matsumoto, Yoshitsugu

AU - Matsunaga, Shigeki

AU - Van Soest, Rob W.M.

AU - Fusetani, Nobuhiro

PY - 2008/3/1

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N2 - Three lipopeptides, ciliatamides A-C (1-3), were isolated from the deep-sea sponge Aaptos ciliata, and their structures were elucidated on the basis of spectroscopic and chemical methods. Ciliatamides A (1) and B (2) were found to be antileishmanial, while 2 also exhibited marginal cytotoxicity to HeLa cells.

AB - Three lipopeptides, ciliatamides A-C (1-3), were isolated from the deep-sea sponge Aaptos ciliata, and their structures were elucidated on the basis of spectroscopic and chemical methods. Ciliatamides A (1) and B (2) were found to be antileishmanial, while 2 also exhibited marginal cytotoxicity to HeLa cells.

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Ciliatamides A-C, bioactive lipopeptides from the deep-sea sponge Aaptos ciliata

Abstract

ASJC Scopus subject areas

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