Clearance and tissue distribution of functionalized polymeric liposomes from the blood stream of rats

Yoh Ichi Matsushita; Kiyoshi Eshima; Takashi Shindo; Yoshio Yamamoto; Etsuo Hasegawa; Hiroyuki Nishide; Eishun Tsuchida

doi:10.1016/0005-2736(87)90269-0

Clearance and tissue distribution of functionalized polymeric liposomes from the blood stream of rats

Yoh Ichi Matsushita, Kiyoshi Eshima, Takashi Shindo, Yoshio Yamamoto, Etsuo Hasegawa, Hiroyuki Nishide, Eishun Tsuchida^*

^*Corresponding author for this work

Waseda Research Institute for Science and Engineering

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Polymeric liposomes containing a synthetic porphinato-iron-imidazole complex (hemoglobin or red blood cell model) were labeled by introducing 1,2-di[1-¹⁴C]palmitoyl-sn-glycero-3-phosphocholine into their polymerized bilayers. After intravenous injection into rats, their clearance from a blood stream was measured. The apparent half-life time (50% disappearance time) was about 14 ± 2 h. Their tissue distribution was determined with time by whole autoradiographic measurement.

Original language	English
Pages (from-to)	166-171
Number of pages	6
Journal	BBA - Biomembranes
Volume	901
Issue number	1
DOIs	https://doi.org/10.1016/0005-2736(87)90269-0
Publication status	Published - 1987 Jul 10

Keywords

Hemoglobin model
Lipid label
Liposome clearance
Oxygen carrier
Polymeric liposome
Tissue distribution

ASJC Scopus subject areas

Biochemistry
Biophysics
Cell Biology
Medicine(all)

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10.1016/0005-2736(87)90269-0

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abstract = "Polymeric liposomes containing a synthetic porphinato-iron-imidazole complex (hemoglobin or red blood cell model) were labeled by introducing 1,2-di[1-14C]palmitoyl-sn-glycero-3-phosphocholine into their polymerized bilayers. After intravenous injection into rats, their clearance from a blood stream was measured. The apparent half-life time (50% disappearance time) was about 14 ± 2 h. Their tissue distribution was determined with time by whole autoradiographic measurement.",

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AU - Matsushita, Yoh Ichi

AU - Eshima, Kiyoshi

AU - Shindo, Takashi

AU - Yamamoto, Yoshio

AU - Hasegawa, Etsuo

AU - Nishide, Hiroyuki

AU - Tsuchida, Eishun

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AB - Polymeric liposomes containing a synthetic porphinato-iron-imidazole complex (hemoglobin or red blood cell model) were labeled by introducing 1,2-di[1-14C]palmitoyl-sn-glycero-3-phosphocholine into their polymerized bilayers. After intravenous injection into rats, their clearance from a blood stream was measured. The apparent half-life time (50% disappearance time) was about 14 ± 2 h. Their tissue distribution was determined with time by whole autoradiographic measurement.

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KW - Lipid label

KW - Liposome clearance

KW - Oxygen carrier

KW - Polymeric liposome

KW - Tissue distribution

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Clearance and tissue distribution of functionalized polymeric liposomes from the blood stream of rats

Abstract

Keywords

ASJC Scopus subject areas

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