Clinical measurement of tumor fluorescence using a new diagnostic system with hematoporphyrin derivative, laser photoradiation, and a spectroscope

Harubumi Kato; Jutaro Ono; Chimori Konaka; Norihiko Kawate; Kazuo Yoneyama; Komei Kinoshita; Katsuaki Nishimiya; Harumasa Sakai; Masayuki Noguchi; Takahisa Tomono; Yoshihiro Hayata; Katsuo Aizawa; Satoru Kawasaki; Yasuaki Tokuda

doi:10.1002/lsm.1900040107

Clinical measurement of tumor fluorescence using a new diagnostic system with hematoporphyrin derivative, laser photoradiation, and a spectroscope

Harubumi Kato^*, Jutaro Ono, Chimori Konaka, Norihiko Kawate, Kazuo Yoneyama, Komei Kinoshita, Katsuaki Nishimiya, Harumasa Sakai, Masayuki Noguchi, Takahisa Tomono, Yoshihiro Hayata, Katsuo Aizawa, Satoru Kawasaki, Yasuaki Tokuda

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Hematoporphyrin derivative (HPD) is retained by malignant tumors and emits fluorescence with peaks of 630 and 690 nm wavelength when HPD is exposed to light. It is therefore theoretically possible to make a diagnosis of malignant tumors by detecting the fluorescence of HPD. The authors developed a spectroscope system compatible with fiberoptic endoscopes to analyze the shape of the fluorescence light spectrum. We could clearly recognize the HPD‐specific fluorescence in human cancer foci. This system can be applied to the measurement of the relative amount of HPD absorbed in superficial tumor tissue before the photodynamic therapy. This might suggest the extent of tumor. The clinical diagnostic applications of this system are described in this study.

Original language	English
Pages (from-to)	49-58
Number of pages	10
Journal	Lasers in Surgery and Medicine
Volume	4
Issue number	1
DOIs	https://doi.org/10.1002/lsm.1900040107
Publication status	Published - 1984
Externally published	Yes

Keywords

autofluorescence
bladder cancer
diagnostic system
hematoporphyrin derivative
krypton ion laser
lung cancer
photofrin II
skin cancer
spectroscope
stomach cancer

ASJC Scopus subject areas

Surgery
Dermatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/lsm.1900040107

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Kato, H., Ono, J., Konaka, C., Kawate, N., Yoneyama, K., Kinoshita, K., Nishimiya, K., Sakai, H., Noguchi, M., Tomono, T., Hayata, Y., Aizawa, K., Kawasaki, S., & Tokuda, Y. (1984). Clinical measurement of tumor fluorescence using a new diagnostic system with hematoporphyrin derivative, laser photoradiation, and a spectroscope. Lasers in Surgery and Medicine, 4(1), 49-58. https://doi.org/10.1002/lsm.1900040107

Kato, H, Ono, J, Konaka, C, Kawate, N, Yoneyama, K, Kinoshita, K, Nishimiya, K, Sakai, H, Noguchi, M, Tomono, T, Hayata, Y, Aizawa, K, Kawasaki, S & Tokuda, Y 1984, 'Clinical measurement of tumor fluorescence using a new diagnostic system with hematoporphyrin derivative, laser photoradiation, and a spectroscope', Lasers in Surgery and Medicine, vol. 4, no. 1, pp. 49-58. https://doi.org/10.1002/lsm.1900040107

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title = "Clinical measurement of tumor fluorescence using a new diagnostic system with hematoporphyrin derivative, laser photoradiation, and a spectroscope",

abstract = "Hematoporphyrin derivative (HPD) is retained by malignant tumors and emits fluorescence with peaks of 630 and 690 nm wavelength when HPD is exposed to light. It is therefore theoretically possible to make a diagnosis of malignant tumors by detecting the fluorescence of HPD. The authors developed a spectroscope system compatible with fiberoptic endoscopes to analyze the shape of the fluorescence light spectrum. We could clearly recognize the HPD‐specific fluorescence in human cancer foci. This system can be applied to the measurement of the relative amount of HPD absorbed in superficial tumor tissue before the photodynamic therapy. This might suggest the extent of tumor. The clinical diagnostic applications of this system are described in this study.",

keywords = "autofluorescence, bladder cancer, diagnostic system, hematoporphyrin derivative, krypton ion laser, lung cancer, photofrin II, skin cancer, spectroscope, stomach cancer",

author = "Harubumi Kato and Jutaro Ono and Chimori Konaka and Norihiko Kawate and Kazuo Yoneyama and Komei Kinoshita and Katsuaki Nishimiya and Harumasa Sakai and Masayuki Noguchi and Takahisa Tomono and Yoshihiro Hayata and Katsuo Aizawa and Satoru Kawasaki and Yasuaki Tokuda",

year = "1984",

doi = "10.1002/lsm.1900040107",

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AU - Kato, Harubumi

AU - Ono, Jutaro

AU - Konaka, Chimori

AU - Kawate, Norihiko

AU - Yoneyama, Kazuo

AU - Kinoshita, Komei

AU - Nishimiya, Katsuaki

AU - Sakai, Harumasa

AU - Noguchi, Masayuki

AU - Tomono, Takahisa

AU - Hayata, Yoshihiro

AU - Aizawa, Katsuo

AU - Kawasaki, Satoru

AU - Tokuda, Yasuaki

PY - 1984

Y1 - 1984

N2 - Hematoporphyrin derivative (HPD) is retained by malignant tumors and emits fluorescence with peaks of 630 and 690 nm wavelength when HPD is exposed to light. It is therefore theoretically possible to make a diagnosis of malignant tumors by detecting the fluorescence of HPD. The authors developed a spectroscope system compatible with fiberoptic endoscopes to analyze the shape of the fluorescence light spectrum. We could clearly recognize the HPD‐specific fluorescence in human cancer foci. This system can be applied to the measurement of the relative amount of HPD absorbed in superficial tumor tissue before the photodynamic therapy. This might suggest the extent of tumor. The clinical diagnostic applications of this system are described in this study.

AB - Hematoporphyrin derivative (HPD) is retained by malignant tumors and emits fluorescence with peaks of 630 and 690 nm wavelength when HPD is exposed to light. It is therefore theoretically possible to make a diagnosis of malignant tumors by detecting the fluorescence of HPD. The authors developed a spectroscope system compatible with fiberoptic endoscopes to analyze the shape of the fluorescence light spectrum. We could clearly recognize the HPD‐specific fluorescence in human cancer foci. This system can be applied to the measurement of the relative amount of HPD absorbed in superficial tumor tissue before the photodynamic therapy. This might suggest the extent of tumor. The clinical diagnostic applications of this system are described in this study.

KW - autofluorescence

KW - bladder cancer

KW - diagnostic system

KW - hematoporphyrin derivative

KW - krypton ion laser

KW - lung cancer

KW - photofrin II

KW - skin cancer

KW - spectroscope

KW - stomach cancer

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DO - 10.1002/lsm.1900040107

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AN - SCOPUS:0021212052

SN - 0196-8092

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SP - 49

EP - 58

JO - Lasers in Surgery and Medicine

JF - Lasers in Surgery and Medicine

IS - 1

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Clinical measurement of tumor fluorescence using a new diagnostic system with hematoporphyrin derivative, laser photoradiation, and a spectroscope

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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