Comparison of outer membrane protein genes omp and pmp in the whole genome sequences of Chlamydia pneumoniae isolates from Japan and the United States

Mutsunori Shirai; Hideki Hirakawa; Kazunobu Ouchi; Mitsuaki Tabuchi; Fumio Kishi; Mitsuaki Kimoto; Hiroaki Takeuchi; Junko Nishida; Kaori Shibata; Ryutaro Fujinaga; Hiroshi Yoneda; Hiroshi Matsushima; Chiho Tanaka; Susumu Furukawa; Koshiro Miura; Atsushi Nakazawa; Kazuo Ishii; Tadayoshi Shiba; Masahira Hattori; Satoru Kuhara; Teruko Nakazawa

Comparison of outer membrane protein genes omp and pmp in the whole genome sequences of Chlamydia pneumoniae isolates from Japan and the United States

Mutsunori Shirai^*, Hideki Hirakawa, Kazunobu Ouchi, Mitsuaki Tabuchi, Fumio Kishi, Mitsuaki Kimoto, Hiroaki Takeuchi, Junko Nishida, Kaori Shibata, Ryutaro Fujinaga, Hiroshi Yoneda, Hiroshi Matsushima, Chiho Tanaka, Susumu Furukawa, Koshiro Miura, Atsushi Nakazawa, Kazuo Ishii, Tadayoshi Shiba, Masahira Hattori, Satoru KuharaTeruko Nakazawa

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Chlamydia pneumoniae is a widespread pathogen of the respiratory tract that is also associated with atherosclerosis. The whole genome sequence was determined for a Japanese isolate, C. pneumoniae strain J 138. The sequence predicted a variety of genes encoding outer membrane proteins (OMPs) including ompA and porB, another 10 predicted omp genes, and 27 pmp genes. All were detected in the whole genome sequence of strain CWL029, a strain isolated and sequenced in the United States. A comparative study of the OMPs of the two strains revealed a nucleotide sequence identity of 89.6%-100% (deduced amino acid sequence identity, 71.1%-100%). The overall genomic organization and location of genes are identical in both strains. Thus, a few unique sequences of the OMPs may be essential for specific attributes that define the differential biology of two C. pneumoniae strains.

Original language	English
Journal	Journal of Infectious Diseases
Volume	181
Issue number	6 SUPPL. 3
Publication status	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Shirai, M., Hirakawa, H., Ouchi, K., Tabuchi, M., Kishi, F., Kimoto, M., Takeuchi, H., Nishida, J., Shibata, K., Fujinaga, R., Yoneda, H., Matsushima, H., Tanaka, C., Furukawa, S., Miura, K., Nakazawa, A., Ishii, K., Shiba, T., Hattori, M., ... Nakazawa, T. (2000). Comparison of outer membrane protein genes omp and pmp in the whole genome sequences of Chlamydia pneumoniae isolates from Japan and the United States. Journal of Infectious Diseases, 181(6 SUPPL. 3).

Shirai, M, Hirakawa, H, Ouchi, K, Tabuchi, M, Kishi, F, Kimoto, M, Takeuchi, H, Nishida, J, Shibata, K, Fujinaga, R, Yoneda, H, Matsushima, H, Tanaka, C, Furukawa, S, Miura, K, Nakazawa, A, Ishii, K, Shiba, T, Hattori, M, Kuhara, S & Nakazawa, T 2000, 'Comparison of outer membrane protein genes omp and pmp in the whole genome sequences of Chlamydia pneumoniae isolates from Japan and the United States', Journal of Infectious Diseases, vol. 181, no. 6 SUPPL. 3.

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abstract = "Chlamydia pneumoniae is a widespread pathogen of the respiratory tract that is also associated with atherosclerosis. The whole genome sequence was determined for a Japanese isolate, C. pneumoniae strain J 138. The sequence predicted a variety of genes encoding outer membrane proteins (OMPs) including ompA and porB, another 10 predicted omp genes, and 27 pmp genes. All were detected in the whole genome sequence of strain CWL029, a strain isolated and sequenced in the United States. A comparative study of the OMPs of the two strains revealed a nucleotide sequence identity of 89.6%-100% (deduced amino acid sequence identity, 71.1%-100%). The overall genomic organization and location of genes are identical in both strains. Thus, a few unique sequences of the OMPs may be essential for specific attributes that define the differential biology of two C. pneumoniae strains.",

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AU - Shirai, Mutsunori

AU - Hirakawa, Hideki

AU - Ouchi, Kazunobu

AU - Tabuchi, Mitsuaki

AU - Kishi, Fumio

AU - Kimoto, Mitsuaki

AU - Takeuchi, Hiroaki

AU - Nishida, Junko

AU - Shibata, Kaori

AU - Fujinaga, Ryutaro

AU - Yoneda, Hiroshi

AU - Matsushima, Hiroshi

AU - Tanaka, Chiho

AU - Furukawa, Susumu

AU - Miura, Koshiro

AU - Nakazawa, Atsushi

AU - Ishii, Kazuo

AU - Shiba, Tadayoshi

AU - Hattori, Masahira

AU - Kuhara, Satoru

AU - Nakazawa, Teruko

PY - 2000

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AB - Chlamydia pneumoniae is a widespread pathogen of the respiratory tract that is also associated with atherosclerosis. The whole genome sequence was determined for a Japanese isolate, C. pneumoniae strain J 138. The sequence predicted a variety of genes encoding outer membrane proteins (OMPs) including ompA and porB, another 10 predicted omp genes, and 27 pmp genes. All were detected in the whole genome sequence of strain CWL029, a strain isolated and sequenced in the United States. A comparative study of the OMPs of the two strains revealed a nucleotide sequence identity of 89.6%-100% (deduced amino acid sequence identity, 71.1%-100%). The overall genomic organization and location of genes are identical in both strains. Thus, a few unique sequences of the OMPs may be essential for specific attributes that define the differential biology of two C. pneumoniae strains.

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Comparison of outer membrane protein genes omp and pmp in the whole genome sequences of Chlamydia pneumoniae isolates from Japan and the United States

Abstract

ASJC Scopus subject areas

UN SDGs

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