Complete nucleotide sequence of the IncN plasmid encoding imp-6 and CTX-M-2 from emerging carbapenem-resistant Enterobacteriaceae in japan

Shizuo Kayama; Norifumi Shigemoto; Ryuichi Kuwahara; Kenshiro Oshima; Hideki Hirakawa; Junzo Hisatsune; Thomas Jové; Hisaaki Nishio; Katsutoshi Yamasaki; Yasunao Wada; Takeshi Ueshimo; Tetsuya Miura; Taijiro Sueda; Makoto Onodera; Michiya Yokozaki; Masahira Hattori; Hiroki Ohge; Motoyuki Sugai

doi:10.1128/AAC.04759

Complete nucleotide sequence of the IncN plasmid encoding imp-6 and CTX-M-2 from emerging carbapenem-resistant Enterobacteriaceae in japan

Shizuo Kayama, Norifumi Shigemoto, Ryuichi Kuwahara, Kenshiro Oshima, Hideki Hirakawa, Junzo Hisatsune, Thomas Jové, Hisaaki Nishio, Katsutoshi Yamasaki, Yasunao Wada, Takeshi Ueshimo, Tetsuya Miura, Taijiro Sueda, Makoto Onodera, Michiya Yokozaki, Masahira Hattori, Hiroki Ohge, Motoyuki Sugai^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

We have determined the DNA sequence of Klebsiella pneumoniae multidrug resistance plasmid pKPI-6, which is a self-transmissible IncN-type plasmid. pKPI-6 harboring bla_IMP-6 and bla_CTX-M-2 confers a stealth-type carbapenem resistance phenotype on members of the family Enterobacteriaceae that is not detectable with imipenem. pKPI-6 is already epidemic in Japan, favoring the dissemination of IMP-6 and CTX-M-2 in members of the family Enterobacteriaceae.

Original language	English
Pages (from-to)	1356-1359
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	2
DOIs	https://doi.org/10.1128/AAC.04759
Publication status	Published - 2015 Feb 1
Externally published	Yes

ASJC Scopus subject areas

Pharmacology (medical)
Pharmacology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.04759

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Kayama, S., Shigemoto, N., Kuwahara, R., Oshima, K., Hirakawa, H., Hisatsune, J., Jové, T., Nishio, H., Yamasaki, K., Wada, Y., Ueshimo, T., Miura, T., Sueda, T., Onodera, M., Yokozaki, M., Hattori, M., Ohge, H., & Sugai, M. (2015). Complete nucleotide sequence of the IncN plasmid encoding imp-6 and CTX-M-2 from emerging carbapenem-resistant Enterobacteriaceae in japan. Antimicrobial Agents and Chemotherapy, 59(2), 1356-1359. https://doi.org/10.1128/AAC.04759

Kayama, S, Shigemoto, N, Kuwahara, R, Oshima, K, Hirakawa, H, Hisatsune, J, Jové, T, Nishio, H, Yamasaki, K, Wada, Y, Ueshimo, T, Miura, T, Sueda, T, Onodera, M, Yokozaki, M, Hattori, M, Ohge, H & Sugai, M 2015, 'Complete nucleotide sequence of the IncN plasmid encoding imp-6 and CTX-M-2 from emerging carbapenem-resistant Enterobacteriaceae in japan', Antimicrobial Agents and Chemotherapy, vol. 59, no. 2, pp. 1356-1359. https://doi.org/10.1128/AAC.04759

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abstract = "We have determined the DNA sequence of Klebsiella pneumoniae multidrug resistance plasmid pKPI-6, which is a self-transmissible IncN-type plasmid. pKPI-6 harboring blaIMP-6 and blaCTX-M-2 confers a stealth-type carbapenem resistance phenotype on members of the family Enterobacteriaceae that is not detectable with imipenem. pKPI-6 is already epidemic in Japan, favoring the dissemination of IMP-6 and CTX-M-2 in members of the family Enterobacteriaceae.",

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AU - Kayama, Shizuo

AU - Shigemoto, Norifumi

AU - Kuwahara, Ryuichi

AU - Oshima, Kenshiro

AU - Hirakawa, Hideki

AU - Hisatsune, Junzo

AU - Jové, Thomas

AU - Nishio, Hisaaki

AU - Yamasaki, Katsutoshi

AU - Wada, Yasunao

AU - Ueshimo, Takeshi

AU - Miura, Tetsuya

AU - Sueda, Taijiro

AU - Onodera, Makoto

AU - Yokozaki, Michiya

AU - Hattori, Masahira

AU - Ohge, Hiroki

AU - Sugai, Motoyuki

PY - 2015/2/1

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AB - We have determined the DNA sequence of Klebsiella pneumoniae multidrug resistance plasmid pKPI-6, which is a self-transmissible IncN-type plasmid. pKPI-6 harboring blaIMP-6 and blaCTX-M-2 confers a stealth-type carbapenem resistance phenotype on members of the family Enterobacteriaceae that is not detectable with imipenem. pKPI-6 is already epidemic in Japan, favoring the dissemination of IMP-6 and CTX-M-2 in members of the family Enterobacteriaceae.

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Complete nucleotide sequence of the IncN plasmid encoding imp-6 and CTX-M-2 from emerging carbapenem-resistant Enterobacteriaceae in japan

Abstract

ASJC Scopus subject areas

UN SDGs

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