Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances

Kohei Kubota; Hideo Kanazawa; Shuji Hisamoto; Shinji Takeoka

Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances

Kohei Kubota^*, Hideo Kanazawa, Shuji Hisamoto, Shinji Takeoka

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

Liposomes of which the surface was modified with poly(ethylene glycol) (PEG) chains are used to prevent aggregation and fusion and to prolong blood circulation. PEG-lipids were immobilized onto the surface of liposomes by simply adding their aqueous dispersions to the liposome dispersions. However, they dissociated from the liposomes by dilution of the mixed dispersions because they were incorporated into the liposomes in an equilibrium state. For the tight immobilization of the PEG-lipids with the long PEG chain onto the liposome surface, an increased number of alkyl chains is necessary.

Original language	English
Number of pages	1
Publication status	Published - 2005 Dec 1
Event	54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: 2005 May 25 → 2005 May 27

Conference

Conference	54th SPSJ Annual Meeting 2005
Country/Territory	Japan
City	Yokohama
Period	05/5/25 → 05/5/27

Keywords

Hydrophilic-hydrophobic balance
Liposome
Multi alkyl chains
Poly(ethylene glycol)-lipid

ASJC Scopus subject areas

Engineering(all)

Cite this

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title = "Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances",

abstract = "Liposomes of which the surface was modified with poly(ethylene glycol) (PEG) chains are used to prevent aggregation and fusion and to prolong blood circulation. PEG-lipids were immobilized onto the surface of liposomes by simply adding their aqueous dispersions to the liposome dispersions. However, they dissociated from the liposomes by dilution of the mixed dispersions because they were incorporated into the liposomes in an equilibrium state. For the tight immobilization of the PEG-lipids with the long PEG chain onto the liposome surface, an increased number of alkyl chains is necessary.",

keywords = "Hydrophilic-hydrophobic balance, Liposome, Multi alkyl chains, Poly(ethylene glycol)-lipid",

author = "Kohei Kubota and Hideo Kanazawa and Shuji Hisamoto and Shinji Takeoka",

year = "2005",

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day = "1",

language = "English",

note = "54th SPSJ Annual Meeting 2005 ; Conference date: 25-05-2005 Through 27-05-2005",

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T1 - Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances

AU - Kubota, Kohei

AU - Kanazawa, Hideo

AU - Hisamoto, Shuji

AU - Takeoka, Shinji

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Liposomes of which the surface was modified with poly(ethylene glycol) (PEG) chains are used to prevent aggregation and fusion and to prolong blood circulation. PEG-lipids were immobilized onto the surface of liposomes by simply adding their aqueous dispersions to the liposome dispersions. However, they dissociated from the liposomes by dilution of the mixed dispersions because they were incorporated into the liposomes in an equilibrium state. For the tight immobilization of the PEG-lipids with the long PEG chain onto the liposome surface, an increased number of alkyl chains is necessary.

AB - Liposomes of which the surface was modified with poly(ethylene glycol) (PEG) chains are used to prevent aggregation and fusion and to prolong blood circulation. PEG-lipids were immobilized onto the surface of liposomes by simply adding their aqueous dispersions to the liposome dispersions. However, they dissociated from the liposomes by dilution of the mixed dispersions because they were incorporated into the liposomes in an equilibrium state. For the tight immobilization of the PEG-lipids with the long PEG chain onto the liposome surface, an increased number of alkyl chains is necessary.

KW - Hydrophilic-hydrophobic balance

KW - Liposome

KW - Multi alkyl chains

KW - Poly(ethylene glycol)-lipid

UR - http://www.scopus.com/inward/record.url?scp=33645645282&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645645282&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33645645282

T2 - 54th SPSJ Annual Meeting 2005

Y2 - 25 May 2005 through 27 May 2005

ER -

Control of the surface modification of liposomes by poly(ethylene glycol)-lipids with different hydrophilic-hydrophobic balances

Abstract

Conference

Keywords

ASJC Scopus subject areas

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