Convulsive Seizures in Schizophrenic Patients Induced by Zotepine Administration

Masashi Hori*, Toshihito Suzuki, Megumi Sasaki, Hiroyasu Shiraishi, Junzo Koizumi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Abstract: One hundred twenty‐nine schizophrenic inpatients who were administered zotepine were studied to see if they had zotepine‐induced convulsive seizures. Twenty‐two patients had grand mal seizures during the administration periods. The incidence of the seizure was 17.1%and was higher than that in previous reports. The average duration of zotepine administration before the seizure was 48.3 days. The incidence of the seizure was closely related to the daily dosage of zotepine, but there was no significant correlation between the daily dosage of zotepine and the duration of administration before the onset of the seizure. The patients who received a combined administration with the higher dose of zotepine and other phenothiazines were revealed to be more likely to have the seizure. In addition, young pateints and patients with a past history of head injuries showed a high incidence of the seizure with the administration of zotepine.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalPsychiatry and Clinical Neurosciences
Issue number1
Publication statusPublished - 1992 Mar
Externally publishedYes


  • convulsive seizures
  • schizophrenic patients
  • zotepine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health


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