Cristaxenicin A, an antiprotozoal xenicane diterpenoid from the deep sea gorgonian acanthoprimnoa cristata

Shin Taro Ishigami; Yasuyuki Goto; Noboru Inoue; Shin Ichiro Kawazu; Yoshitsugu Matsumoto; Yukimitsu Imahara; Moto Tarumi; Hiromi Nakai; Nobuhiro Fusetani; Yoichi Nakao

doi:10.1021/jo302109g

Cristaxenicin A, an antiprotozoal xenicane diterpenoid from the deep sea gorgonian acanthoprimnoa cristata

Shin Taro Ishigami, Yasuyuki Goto, Noboru Inoue, Shin Ichiro Kawazu, Yoshitsugu Matsumoto, Yukimitsu Imahara, Moto Tarumi, Hiromi Nakai, Nobuhiro Fusetani, Yoichi Nakao^*

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

A new xenicane diterpenoid, cristaxenicin A (1), has been isolated from the deep sea gorgonian Acanthoprimnoa cristata. The structure of 1 was elucidated on the basis of spectral analysis including NMR and MS. The absolute configuration of 1 was determined on the basis of quantum chemical calculation of CD spectra. Cristaxenicin A (1) showed antiprotozoal activities against Leishmania amazonensis and Trypanosoma congolense with IC₅₀ values of 0.088 and 0.25 μM, respectively.

Original language	English
Pages (from-to)	10962-10966
Number of pages	5
Journal	Journal of Organic Chemistry
Volume	77
Issue number	23
DOIs	https://doi.org/10.1021/jo302109g
Publication status	Published - 2012 Dec 7

ASJC Scopus subject areas

Organic Chemistry

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abstract = "A new xenicane diterpenoid, cristaxenicin A (1), has been isolated from the deep sea gorgonian Acanthoprimnoa cristata. The structure of 1 was elucidated on the basis of spectral analysis including NMR and MS. The absolute configuration of 1 was determined on the basis of quantum chemical calculation of CD spectra. Cristaxenicin A (1) showed antiprotozoal activities against Leishmania amazonensis and Trypanosoma congolense with IC50 values of 0.088 and 0.25 μM, respectively.",

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doi = "10.1021/jo302109g",

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T1 - Cristaxenicin A, an antiprotozoal xenicane diterpenoid from the deep sea gorgonian acanthoprimnoa cristata

AU - Ishigami, Shin Taro

AU - Goto, Yasuyuki

AU - Inoue, Noboru

AU - Kawazu, Shin Ichiro

AU - Matsumoto, Yoshitsugu

AU - Imahara, Yukimitsu

AU - Tarumi, Moto

AU - Nakai, Hiromi

AU - Fusetani, Nobuhiro

AU - Nakao, Yoichi

PY - 2012/12/7

Y1 - 2012/12/7

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AB - A new xenicane diterpenoid, cristaxenicin A (1), has been isolated from the deep sea gorgonian Acanthoprimnoa cristata. The structure of 1 was elucidated on the basis of spectral analysis including NMR and MS. The absolute configuration of 1 was determined on the basis of quantum chemical calculation of CD spectra. Cristaxenicin A (1) showed antiprotozoal activities against Leishmania amazonensis and Trypanosoma congolense with IC50 values of 0.088 and 0.25 μM, respectively.

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Cristaxenicin A, an antiprotozoal xenicane diterpenoid from the deep sea gorgonian acanthoprimnoa cristata

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