TY - JOUR
T1 - Cyclic change of cytokines in a patient with cyclic thrombocytopenia
AU - Kimura, Fumihiko
AU - Nakamura, Yukistugu
AU - Sato, Ken
AU - Wakimoto, Naoki
AU - Kato, Takashi
AU - Tahara, Tomoyuki
AU - Yamada, Muneo
AU - Nagata, Naokazu
AU - Motoyoshi, Kazuo
PY - 1996
Y1 - 1996
N2 - The serial change of various cytokines in the serum from a patient with cyclic thrombocytopenia is described, Interleukin 7, stem cell factor, and transforming growth factor β1 synchronized with the platelet count, and there was a significant positive correlation between the three cytokines and the platelet count. Levels of macrophage colony-stimulating factor, thrombopoietin, platelet-associated IgG and erythropoietin changed reciprocally with the platelet count, and there was a significant negative correlation between the platelet count and these cytokines except erythropoietin. No cyclic change was observed in IL-3, IL-6, IL-11, granulocyte-macrophage colony-stimulating factor, or leukaemia inhibitory factor. These observations suggest that this disease involves two cyclic changes: megakaryocytopoiesis and platelet destruction, in both of which the cytokines play an important role.
AB - The serial change of various cytokines in the serum from a patient with cyclic thrombocytopenia is described, Interleukin 7, stem cell factor, and transforming growth factor β1 synchronized with the platelet count, and there was a significant positive correlation between the three cytokines and the platelet count. Levels of macrophage colony-stimulating factor, thrombopoietin, platelet-associated IgG and erythropoietin changed reciprocally with the platelet count, and there was a significant negative correlation between the platelet count and these cytokines except erythropoietin. No cyclic change was observed in IL-3, IL-6, IL-11, granulocyte-macrophage colony-stimulating factor, or leukaemia inhibitory factor. These observations suggest that this disease involves two cyclic changes: megakaryocytopoiesis and platelet destruction, in both of which the cytokines play an important role.
KW - Cyclic thrombocytopenia
KW - Interleukin-7
KW - M-CSF
KW - Stem cell factor
KW - Thrombopoietin
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U2 - 10.1046/j.1365-2141.1996.d01-1783.x
DO - 10.1046/j.1365-2141.1996.d01-1783.x
M3 - Article
C2 - 8757531
AN - SCOPUS:0030016135
SN - 0007-1048
VL - 94
SP - 171
EP - 174
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 1
ER -