Cyclic change of cytokines in a patient with cyclic thrombocytopenia

Fumihiko Kimura, Yukistugu Nakamura, Ken Sato, Naoki Wakimoto, Takashi Kato, Tomoyuki Tahara, Muneo Yamada, Naokazu Nagata, Kazuo Motoyoshi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


The serial change of various cytokines in the serum from a patient with cyclic thrombocytopenia is described, Interleukin 7, stem cell factor, and transforming growth factor β1 synchronized with the platelet count, and there was a significant positive correlation between the three cytokines and the platelet count. Levels of macrophage colony-stimulating factor, thrombopoietin, platelet-associated IgG and erythropoietin changed reciprocally with the platelet count, and there was a significant negative correlation between the platelet count and these cytokines except erythropoietin. No cyclic change was observed in IL-3, IL-6, IL-11, granulocyte-macrophage colony-stimulating factor, or leukaemia inhibitory factor. These observations suggest that this disease involves two cyclic changes: megakaryocytopoiesis and platelet destruction, in both of which the cytokines play an important role.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalBritish Journal of Haematology
Issue number1
Publication statusPublished - 1996
Externally publishedYes


  • Cyclic thrombocytopenia
  • Interleukin-7
  • M-CSF
  • Stem cell factor
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology


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