Cytotoxic C47-polyacetylene carboxylic acids from a marine sponge Pertrosia sp

Chikane Okamoto; Yoichi Nakao; Tsuyoshi Fujita; Takashi Iwashita; Rob W.M. Van Soest; Nobuhiro Fusetani; Shigeki Matsunaga

doi:10.1021/np0702943

Cytotoxic C₄₇-polyacetylene carboxylic acids from a marine sponge Pertrosia sp

Chikane Okamoto, Yoichi Nakao, Tsuyoshi Fujita, Takashi Iwashita, Rob W.M. Van Soest, Nobuhiro Fusetani, Shigeki Matsunaga^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Two new polyacetylene carboxylic acids, petroformynic acids B (3) and C (4), were isolated from a marine sponge Pertrosia sp. as cytotoxic constituents. Their structures were determined by interpretation of 2D NMR data and tandem FABMS data. Absolute stereochemistry of 3 was assigned by application of the modified Mosher analysis. Petroformynic acids exhibit moderate cytotoxic activity against P388 cells.

Original language	English
Pages (from-to)	1816-1819
Number of pages	4
Journal	Journal of Natural Products
Volume	70
Issue number	11
DOIs	https://doi.org/10.1021/np0702943
Publication status	Published - 2007 Nov
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/np0702943

Cite this

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AU - Van Soest, Rob W.M.

AU - Fusetani, Nobuhiro

AU - Matsunaga, Shigeki

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