Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae

Yoshihiro Watanabe; Takuya Suga; Satomi Narusawa; Masato Iwatsuki; Kenichi Nonaka; Takuji Nakashima; Yasuo Shinohara; Takahiro Shiotsuki; Naoya Ichimaru; Hideto Miyoshi; Yukihiro Asami; Satoshi Omura; Kazuro Shiomi

doi:10.1038/ja.2016.164

Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae

Yoshihiro Watanabe, Takuya Suga, Satomi Narusawa, Masato Iwatsuki, Kenichi Nonaka, Takuji Nakashima, Yasuo Shinohara, Takahiro Shiotsuki, Naoya Ichimaru, Hideto Miyoshi, Yukihiro Asami, Satoshi Omura, Kazuro Shiomi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A new decalin, decatamariic acid, was isolated from a cultured broth of the fungus Aspergillus tamarii FKI-6817. Its absolute configuration was elucidated by NMR and electronic circular dichroism. Decatamariic acid (10 μM) elicited ∼50% inhibition of the ATP production in mitochondria isolated from wild-type Saccharomyces cerevisiae without affecting the activities of respiratory enzymes. The action manner of this compound may be interesting as a possible seed for new pesticides.

Original language	English
Pages (from-to)	395-399
Number of pages	5
Journal	Journal of Antibiotics
Volume	70
Issue number	4
DOIs	https://doi.org/10.1038/ja.2016.164
Publication status	Published - 2017 Apr 1
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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Watanabe, Y., Suga, T., Narusawa, S., Iwatsuki, M., Nonaka, K., Nakashima, T., Shinohara, Y., Shiotsuki, T., Ichimaru, N., Miyoshi, H., Asami, Y., Omura, S., & Shiomi, K. (2017). Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae. Journal of Antibiotics, 70(4), 395-399. https://doi.org/10.1038/ja.2016.164

Watanabe, Y, Suga, T, Narusawa, S, Iwatsuki, M, Nonaka, K, Nakashima, T, Shinohara, Y, Shiotsuki, T, Ichimaru, N, Miyoshi, H, Asami, Y, Omura, S & Shiomi, K 2017, 'Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae', Journal of Antibiotics, vol. 70, no. 4, pp. 395-399. https://doi.org/10.1038/ja.2016.164

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AU - Watanabe, Yoshihiro

AU - Suga, Takuya

AU - Narusawa, Satomi

AU - Iwatsuki, Masato

AU - Nonaka, Kenichi

AU - Nakashima, Takuji

AU - Shinohara, Yasuo

AU - Shiotsuki, Takahiro

AU - Ichimaru, Naoya

AU - Miyoshi, Hideto

AU - Asami, Yukihiro

AU - Omura, Satoshi

AU - Shiomi, Kazuro

PY - 2017/4/1

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Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae

Abstract

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