Decreased serum brain-derived neurotrophic factor in trained men

Yu Nofuji, Masataka Suwa, Yoshihiko Moriyama, Hiroshi Nakano, Atsushi Ichimiya, Reiko Nishichi, Haruka Sasaki, Zsolt Radak, Shuzo Kumagai*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

81 Citations (Scopus)


The purpose of this study was to clarify the effect of physical activity on the level of serum brain-derived neurotrophic factor (BDNF). The serum BDNF level in trained men who have participated in regular sport activity (n = 12) was compared to that in sedentary subjects (n = 14). The physical activity levels expressed as total energy expenditure, move-related energy expenditure and walking count in the trained were significantly higher than those in the sedentary. The serum BDNF level in the trained men was found to be lower than that in the sedentary (19.54 ± 4.53 ng/ml vs. 23.63 ± 2.94 ng/ml, respectively, P < 0.01). The serum BDNF level showed a significant negative correlation with daily total energy expenditure (r = -0.507, P < 0.05), movement-related energy expenditure (r = -0.503, P < 0.05), and walking count (r = -0.480, P < 0.05). These results may suggest that vigorous habitual physical activity decrease the serum BDNF level.

Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 2008 May 23
Externally publishedYes


  • Brain-derived neurotrophic factor
  • Energy expenditure
  • Physical activity

ASJC Scopus subject areas

  • General Neuroscience


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