Development of a carboplatin derivative conjugated with a collagen-like triple-helical peptide

Ryo Masuda; Risa Hayashi; Hiroshi Nose; Akihiro Taguchi; Yoshio Hayashi; Hiroyuki Yasui; Takaki Koide

doi:10.4155/fmc-2017-0183

Development of a carboplatin derivative conjugated with a collagen-like triple-helical peptide

Ryo Masuda, Risa Hayashi, Hiroshi Nose, Akihiro Taguchi, Yoshio Hayashi, Hiroyuki Yasui, Takaki Koide^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Aim: The development of a platinum anticancer agent that has improved efficacy by efficient delivery to a tumor and that suppresses side effects has been investigated. Arginine-rich triple-helical peptides are promising drug carriers because of their stability in body fluids and cell-penetrating activity. Results: We synthesized a carboplatin derivative conjugated with an arginine-rich triple-helical peptide. This derivative released platinum under acidic conditions or in the presence Cl^- ions. Administration of this derivative to P388 tumor-bearing mice showed comparable survival rates to twice the dose of carboplatin, which was attributed to a longer mean residence time by pharmacokinetics analysis. Conclusion: The collagen-like triple-helical peptide was an efficient carrier of a platinum anticancer agent because of a modification to its pharmacokinetic profile.

Original language	English
Pages (from-to)	619-629
Number of pages	11
Journal	Future Medicinal Chemistry
Volume	10
Issue number	6
DOIs	https://doi.org/10.4155/fmc-2017-0183
Publication status	Published - 2018 Mar

Keywords

antitumor agent
pharmacokinetics
triple-helical peptide

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery

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title = "Development of a carboplatin derivative conjugated with a collagen-like triple-helical peptide",

abstract = "Aim: The development of a platinum anticancer agent that has improved efficacy by efficient delivery to a tumor and that suppresses side effects has been investigated. Arginine-rich triple-helical peptides are promising drug carriers because of their stability in body fluids and cell-penetrating activity. Results: We synthesized a carboplatin derivative conjugated with an arginine-rich triple-helical peptide. This derivative released platinum under acidic conditions or in the presence Cl- ions. Administration of this derivative to P388 tumor-bearing mice showed comparable survival rates to twice the dose of carboplatin, which was attributed to a longer mean residence time by pharmacokinetics analysis. Conclusion: The collagen-like triple-helical peptide was an efficient carrier of a platinum anticancer agent because of a modification to its pharmacokinetic profile.",

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author = "Ryo Masuda and Risa Hayashi and Hiroshi Nose and Akihiro Taguchi and Yoshio Hayashi and Hiroyuki Yasui and Takaki Koide",

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T1 - Development of a carboplatin derivative conjugated with a collagen-like triple-helical peptide

AU - Masuda, Ryo

AU - Hayashi, Risa

AU - Nose, Hiroshi

AU - Taguchi, Akihiro

AU - Hayashi, Yoshio

AU - Yasui, Hiroyuki

AU - Koide, Takaki

PY - 2018/3

Y1 - 2018/3

N2 - Aim: The development of a platinum anticancer agent that has improved efficacy by efficient delivery to a tumor and that suppresses side effects has been investigated. Arginine-rich triple-helical peptides are promising drug carriers because of their stability in body fluids and cell-penetrating activity. Results: We synthesized a carboplatin derivative conjugated with an arginine-rich triple-helical peptide. This derivative released platinum under acidic conditions or in the presence Cl- ions. Administration of this derivative to P388 tumor-bearing mice showed comparable survival rates to twice the dose of carboplatin, which was attributed to a longer mean residence time by pharmacokinetics analysis. Conclusion: The collagen-like triple-helical peptide was an efficient carrier of a platinum anticancer agent because of a modification to its pharmacokinetic profile.

AB - Aim: The development of a platinum anticancer agent that has improved efficacy by efficient delivery to a tumor and that suppresses side effects has been investigated. Arginine-rich triple-helical peptides are promising drug carriers because of their stability in body fluids and cell-penetrating activity. Results: We synthesized a carboplatin derivative conjugated with an arginine-rich triple-helical peptide. This derivative released platinum under acidic conditions or in the presence Cl- ions. Administration of this derivative to P388 tumor-bearing mice showed comparable survival rates to twice the dose of carboplatin, which was attributed to a longer mean residence time by pharmacokinetics analysis. Conclusion: The collagen-like triple-helical peptide was an efficient carrier of a platinum anticancer agent because of a modification to its pharmacokinetic profile.

KW - antitumor agent

KW - pharmacokinetics

KW - triple-helical peptide

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Development of a carboplatin derivative conjugated with a collagen-like triple-helical peptide

Abstract

Keywords

ASJC Scopus subject areas

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