Developmental neurotoxicity of dioxin and its related compounds

Masaki Kakeyama*, Chiharu Tohyama

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

63 Citations (Scopus)


This manuscript reviewed the neurotoxicity of dioxins and related compounds with an emphasis on maternal exposure. The brain during developmental period is thought to be highly sensitive to dioxin and its related compounds that affect a broad range of brain functions from the advanced brain function to the reproduction-controlling function, even at low doses. It is suggested that dioxins exhibit endocrine-disrupting action on the gonadal and thyroid hormone axes, as well as the 'neural-disrupting action' on neural transmission and neural network formation. From behavioral toxicological studies as well as studies on the underlying mechanisms of dioxins' toxicity, dioxins affect some specific functions in particular regions or cells of the brain at critical windows during the developmental period.

Original languageEnglish
Pages (from-to)215-230
Number of pages16
JournalIndustrial Health
Issue number3
Publication statusPublished - 2003 Jul
Externally publishedYes


  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)
  • Brain development
  • Glial cell
  • Neuron
  • Polychrorinated biphenyl (PCB)

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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