TY - JOUR
T1 - Difference in self-assembling morphology of peptide nanorings
AU - Okamoto, Hajime
AU - Yamada, Tetsuo
AU - Miyazaki, Hiroshi
AU - Nakanishi, Tsutomu
AU - Takeda, Kyozaburo
AU - Usui, Kenji
AU - Obataya, Ikuo
AU - Mhara, Hisakazu
AU - Azehara, Hiroaki
AU - Mizutani, Wataru
AU - Hashimoto, Katsushi
AU - Yamaguchi, Hiroshi
AU - Hirayama, Yoshiro
PY - 2005/11/9
Y1 - 2005/11/9
N2 - We synthesized the peptide nanorings of cyclo[-(D-Ala-L-Gln)3], cyclo[-(D-Cys-L-Gln)3], cyclo[-D-Cys-L-His-D-Ala-L-Asn-Gly-L-Gln-] and cyclo[-(L-Gln)3], and studied the way in which the difference in the type and/or number of component amino acid residues changes the self-assembling morphology of the nanorings on gold substrates by atomic force microscopy. The study revealed that cyclo[-(D-Ala-L-Gln)3] formed nanotube bundles through inter-ring hydrogen bonds, while the nanorings of cyclo[-(D-Cys-L-Gln)3] adhered to the gold surface directly due to the high affinity of thiol to gold. In contrast, a random amino acid sequence of cyclo[-D-Cys-L-His-D-Ala-L-Asn-Gly-L-Gln-] resulted in many isolated nanotubes, which were first observed in the present study. While the D,L-peptide nanotubes have very straight forms, the homo-L-peptide of cyclo[-(L-Gln)5] formed interesting randomly branching nanotubes that were entwined and grew on the substrate. Scanning tunneling microscopy was also performed and high-resolution images of both the peptide nanotubes and the nanotube bundles were obtained.
AB - We synthesized the peptide nanorings of cyclo[-(D-Ala-L-Gln)3], cyclo[-(D-Cys-L-Gln)3], cyclo[-D-Cys-L-His-D-Ala-L-Asn-Gly-L-Gln-] and cyclo[-(L-Gln)3], and studied the way in which the difference in the type and/or number of component amino acid residues changes the self-assembling morphology of the nanorings on gold substrates by atomic force microscopy. The study revealed that cyclo[-(D-Ala-L-Gln)3] formed nanotube bundles through inter-ring hydrogen bonds, while the nanorings of cyclo[-(D-Cys-L-Gln)3] adhered to the gold surface directly due to the high affinity of thiol to gold. In contrast, a random amino acid sequence of cyclo[-D-Cys-L-His-D-Ala-L-Asn-Gly-L-Gln-] resulted in many isolated nanotubes, which were first observed in the present study. While the D,L-peptide nanotubes have very straight forms, the homo-L-peptide of cyclo[-(L-Gln)5] formed interesting randomly branching nanotubes that were entwined and grew on the substrate. Scanning tunneling microscopy was also performed and high-resolution images of both the peptide nanotubes and the nanotube bundles were obtained.
KW - Atomic force microscopy
KW - Cyclic peptide
KW - Nanotube
KW - Scanning tunneling microscopy
KW - Self-assembly, synthesis
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U2 - 10.1143/JJAP.44.8240
DO - 10.1143/JJAP.44.8240
M3 - Article
AN - SCOPUS:31544448254
SN - 0021-4922
VL - 44
SP - 8240
EP - 8248
JO - Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers
JF - Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers
IS - 11
ER -