Distribution of novel RFamide-related peptide-like immunoreactivity in the mouse central nervous system

Kazuyoshi Ukena*, Kazuyoshi Tsutsui

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

97 Citations (Scopus)


Recently, novel mammalian RFamide-related peptides (RFRPs) have been identified and suggested to increase prolactin release in the rodent. To assess possible functions of RFRPs, we investigated the distribution of RFRPs in the mouse central nervous system by immunochemical analyses. The quantitative analysis revealed that the concentration of RFRP-like substances was much higher in the brainstem and spinal cord than in other regions. Immunohistochemistry showed that RFRP-like immunoreactive perikarya were localized in the dorsomedial hypothalamic nucleus, the lateral superior olive, and the nucleus of the solitary tract. The dense networks of immunoreactive fibers were found in the lateral parabrachial nucleus, the lateral reticular nucleus, and the superficial layer of spinal trigeminal nucleus and dorsal horn of the spinal cord. Thus, RFRPs may participate not only in neuroendocrine functions but also in behavioral, sensory, and autonomic functions.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalNeuroscience Letters
Issue number3
Publication statusPublished - 2001 Mar 16
Externally publishedYes


  • Central nervous system
  • Enzyme-linked immunosorbent assay
  • Immunohistochemistry
  • Mouse
  • RFamide-related peptide

ASJC Scopus subject areas

  • Neuroscience(all)


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