Diurnal changes in the synthesis of the neurosteroid 7α- hydroxypregnenolone stimulating locomotor activity in newts

Teppei Koyama; Shogo Haraguchi; Hubert Vaudry; Kazuyoshi Tsutsui

doi:10.1111/j.1749-6632.2008.03622.x

Diurnal changes in the synthesis of the neurosteroid 7α- hydroxypregnenolone stimulating locomotor activity in newts

Teppei Koyama, Shogo Haraguchi, Hubert Vaudry, Kazuyoshi Tsutsui^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

10 Citations (Scopus)

Abstract

We recently identified 7α-hydroxypregnenolone as a novel amphibian neurosteroid stimulating locomotor activity in newts. Because male newts show marked diurnal changes in locomotor activity, we hypothesized that 7α-hydroxypregnenolone may be a key factor for the induction of diurnal changes in locomotor activity in male newts. In this study, we found diurnal changes in 7α-hydroxypregnenolone synthesis in the brain of male newts, which paralleled locomotor activity. Interestingly, the production of 7α-hydroxypregnenolone in the male newt brain increased during the dark phase when locomotor activity of males was high.

Original language	English
Title of host publication	Annals of the New York Academy of Sciences
Pages	444-447
Number of pages	4
Volume	1163
DOIs	https://doi.org/10.1111/j.1749-6632.2008.03622.x
Publication status	Published - 2009 Apr

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1163
ISSN (Print)	00778923
ISSN (Electronic)	17496632

Keywords

7α-hydroxypregnenolone
Diurnal changes
Locomotor activity
Neurosteroids
Newts

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1111/j.1749-6632.2008.03622.x

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Diurnal changes in the synthesis of the neurosteroid 7α- hydroxypregnenolone stimulating locomotor activity in newts. / Koyama, Teppei; Haraguchi, Shogo; Vaudry, Hubert et al.
Annals of the New York Academy of Sciences. Vol. 1163 2009. p. 444-447 (Annals of the New York Academy of Sciences; Vol. 1163).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Tsutsui, Kazuyoshi

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Diurnal changes in the synthesis of the neurosteroid 7α- hydroxypregnenolone stimulating locomotor activity in newts

Abstract

Publication series

Keywords

ASJC Scopus subject areas

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