Diversity in the chemotactic behavior of physarum plasmodium induced by bi-modal stimuli

Tomohiro Shirakawa*, Yukio Pegio Gunji, Hiroshi Sato, Hiroto Tsubakino

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


The plasmodium of the true slime mold Physarum polycephalum is a unicellular, multinuclear giant amoeba that is attracting much attention in the field of bio-computing as a living computing substrate. To observe how the plasmodium of Physarum polycephalum responds to a contradictory situation, in which there is no single optimal solution, we applied bi-modal stimuli, consisting of a mixture of an attractant and a repellent, to plasmodia. The plasmodia showed diverse responses that could not be explained by a simple model of the stimulus-response system. We constructed a simulation model of the behavior that replicated the behavioral diversity with a simple combination of molecular apparatuses. In summary, we demonstrated the diversity of the behaviors of the plasmodium and how these behaviors may arise.

Original languageEnglish
Pages (from-to)275-285
Number of pages11
JournalInternational Journal of Unconventional Computing
Issue number4
Publication statusPublished - 2020


  • Amoeba-based computing
  • Behavior
  • Bio-computing
  • Chemotaxis
  • Decision making
  • Physarum plasmodium

ASJC Scopus subject areas

  • Computer Science(all)


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