Docosahexaenoic acid-rich fish oil does not affect serum lipid concentrations of normolipidemic young adults

Tomohito Hamazaki*, Shigeki Sawazaki, Etsuko Asaoka, Miho Itomura, Yutaka Mizushima, Kazunaga Yazawa, Toyomi Kuwamori, Masashi Kobayashi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Fish oils, purified eicosapentaenoic acid and docosahexaenoic acid (DHA) have been reported to improve blood lipid concentrations, especially those of triglycerides in humans. However, to our knowledge there have been no double- blind studies investigating the effects of DHA-rich fish oil on blood lipid concentrations. Therefore, we conducted a placebo-controlled double-blind study. Twenty-four healthy, normolipidemic young adults took either DHA-rich fish oil capsules containing 1.5-1.8 g of DHA or control oil capsules containing 97% soybean oil and 3% fish oil for 13 wk. Blood samples were taken at the start and end of the study, and serum lipids concentrations were compared. There were no significant changes over time in the DHA group in the following serum lipids: total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, lipoprotein(a), and apolipoproteins A1 and B. In contrast, apolipoprotein A1 concentrations slightly (10%) but significantly increased over time in the control group. Docosahexaenoic acid at a dose of less than 2 g/d did not change serum lipid concentrations of normolipidemic subjects. The effects of DHA in hyperlipidemic patients remain to be investigated in a double-blind study.

Original languageEnglish
Pages (from-to)2784-2789
Number of pages6
JournalJournal of Nutrition
Issue number11
Publication statusPublished - 1996 Nov
Externally publishedYes


  • cholesterol
  • docosahexaenoic acid
  • humans
  • lipids
  • lipoprotein(a)
  • serum

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science


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