Donepezil-induced sleep spindle in a patient with dementia with Lewy bodies: A case report

Asami Ozaki, Masaki Nishida*, Keiko Koyama, Kinya Ishikawa, Toru Nishikawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Here, we report a case of rapid eye movement sleep behavioural disorder in an elderly patient with dementia with Lewy bodies. Pretreatment polysomnography revealed atonia during rapid eye movement sleep, absence of sleep spindles and loss of slow-wave sleep. Administration of donepezil, an acetylcholinesterase inhibitor, markedly improved delusional symptoms and cognitive function. Pretreatment polysomnography performed after donepezil administration revealed a considerable number of sleep spindles. The effects of cholinergic modulation induced by donepezil seemed to cause remarkable improvement in mental status, incorporating associated with sleep spindles generated by the thalamocortical circuit involved in this patient.

Original languageEnglish
Pages (from-to)255-258
Number of pages4
Issue number4
Publication statusPublished - 2012 Dec
Externally publishedYes


  • Acetylcholine
  • DLB
  • Donepezil
  • Polysomnography
  • Sleep spindle

ASJC Scopus subject areas

  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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