TY - JOUR
T1 - Early-life stress induces cognitive disorder in middle-aged mice
AU - Yajima, Hiroyuki
AU - Haijima, Asahi
AU - Khairinisa, Miski Aghnia
AU - Shimokawa, Noriaki
AU - Amano, Izuki
AU - Takatsuru, Yusuke
N1 - Funding Information:
This work was supported by a Grants-in-Aid for Scientific Research on Innovative Areas (17H05919) from Japan Society for the Promotion of Science (JSPS), Gunma University Tenure-Track Program, and Hiroshi and Aya Irisawa Memorial Promotion Award for Young Physiologists to YT. The authors thank Prof. Noriyuki Koibuchi for giving us the chance to perform the study.
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/4
Y1 - 2018/4
N2 - Early-life stress can induce several neuropsychological disorders in adulthood. However, the underlying mechanisms inducing such disorders are still not fully understood. Furthermore, the effects of early-life stress on the changes in cognitive function with age are still not clarified. In this study, we used maternal deprivation (MD) to examine the cognitive function in middle-aged mice using a touchscreen-equipped operant chamber. In the visual-discrimination task, the aged (∼1.4 years old) control mice could accurately learn to discriminate between different visual stimuli. In contrast, the correct response rate of aged MD mice increased to ∼60% by day 10; it was still significantly lower than that of the control mice (85%). In the hippocampus of aged MD mice, the expression level of the N-methyl-d-aspartate receptor subunit GluN1 decreased significantly as compared to that in control mice. On the other hand, no significant difference in GluN1 expression level was detected in young (2.5 months old) mice. These findings indicate that early-life stress accelerates cognitive impairment in middle-aged mice.
AB - Early-life stress can induce several neuropsychological disorders in adulthood. However, the underlying mechanisms inducing such disorders are still not fully understood. Furthermore, the effects of early-life stress on the changes in cognitive function with age are still not clarified. In this study, we used maternal deprivation (MD) to examine the cognitive function in middle-aged mice using a touchscreen-equipped operant chamber. In the visual-discrimination task, the aged (∼1.4 years old) control mice could accurately learn to discriminate between different visual stimuli. In contrast, the correct response rate of aged MD mice increased to ∼60% by day 10; it was still significantly lower than that of the control mice (85%). In the hippocampus of aged MD mice, the expression level of the N-methyl-d-aspartate receptor subunit GluN1 decreased significantly as compared to that in control mice. On the other hand, no significant difference in GluN1 expression level was detected in young (2.5 months old) mice. These findings indicate that early-life stress accelerates cognitive impairment in middle-aged mice.
KW - Aging
KW - Behavioral and cognitive neuroscience
KW - Maternal deprivation
KW - NMDA receptor
KW - Touch panel operant task
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U2 - 10.1016/j.neurobiolaging.2017.12.021
DO - 10.1016/j.neurobiolaging.2017.12.021
M3 - Article
C2 - 29458841
AN - SCOPUS:85041387069
SN - 0197-4580
VL - 64
SP - 139
EP - 146
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -