Effect of Coenzyme Q 10 supplementation on, exercise-induced muscular injury of rats

Michihiro Kon, Fuminori Kimura, Takayuki Akimoto, Kai Tanabe, Yosuke Murase, Sachiko Ikemune, Ichiro Kono*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


Aim: We aimed to examine the effect of Coenzyme Q 10 (CoQ 10) supplementation on the exhaustive exercise-induced injury and oxidative stress in skeletal muscle and liver. Methods: Rats were divided into four groups: rest group [control (Con)-Rest; n = 6)], exercise group (Con-Ex; n = 6), rest group with CoQ 10 supplement (CoQ 10- Rest; n = 6), and exercise group with CoQ 10 supplement (CoQ 10-Ex; n = 6). The exercise groups were run on a treadmill until exhaustion. The CoQ 10 supplemented groups received an oral administration of CoQ 10 (300 mg kg -1, 4 weeks). After 4 weeks, total CoQ concentration, creatine kinase (CK), glutamic-oxaloacetic transaminase (GOT), malondialdehyde (MDA), scavenging activity against reactive oxygen species [ROS; superoxide anions (O 2·-) and hydroxyl radicals (HO·)] were measured. Results: Total CoQ concentration in plasma, slow-twitch muscles (soleus and gastronemius deep portion), and liver were significantly increased by CoQ 10 supplementation. Plasma CK was significantly higher in Con-Ex compared with Con-Rest, whereas there was no difference between CoQ 10-Rest and CoQ 10-Ex. There were no significant differences in muscle MDA in each group. Plasma GOT and liver MDA in exercise groups were significantly higher than that of rest groups, but not significantly different between CoQ 10 supplemented groups and control groups. CoQ 10 supplementation was not able to favorably influence ROS scavenging activity in skeletal muscle and liver. Conclusions: These data indicated that CoQ 10 supplementation increased total CoQ concentration in the slow-twitch muscles, and was useful for reducing exhaustive exercise-induced muscular injury by enhancing stabilization of muscle cell membrane.

Original languageEnglish
Pages (from-to)76-88
Number of pages13
JournalExercise immunology review
Publication statusPublished - 2007


  • Coenzyme Q
  • Intense exercise
  • Muscle damage
  • Oxidative stress

ASJC Scopus subject areas

  • Medicine(all)


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