Effect of magnetite nanoparticles on living rate of MCF-7 human breast cancer cells

Daisuke Baba, Yasuhiro Seiko, Takuya Nakanishi, Hong Zhang, Atsushi Arakaki, Tadashi Matsunaga, Tetsuya Osaka*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Superparamagnetic and ferromagnetic magnetite nanoparticles, with diameters of approximately 13 and 44. nm, respectively, were synthesized and their uptake amount and heating efficiency were evaluated for application to magnetic hyperthermia. Both nanoparticles had almost the same zeta-potential (+10.2. mV) and hydrodynamic size (~1μm) and there was no significant difference in their uptake amount 18. h after they were added to the medium. After internalization, the ferromagnetic nanoparticles incorporated in human breast cancer cells (MCF-7) showed a higher heating efficiency than the superparamagnetic nanoparticles when an external magnetic field (4. kW, 250. kHz) high enough to produce heat by hysteresis loss was applied, followed by cellular death of MCF-7 with high ferromagnetic nanoparticle content.

Original languageEnglish
Pages (from-to)254-257
Number of pages4
JournalColloids and Surfaces B: Biointerfaces
Publication statusPublished - 2012 Jun 15


  • Cancer
  • Magnetic hyperthermia
  • Magnetism
  • Magnetite nanoparticles
  • Uptake

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry


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