TY - JOUR
T1 - Effect of quetiapine on Per1, Per2, and Bmal1 clock gene expression in the mouse amygdala and hippocampus
AU - Moriya, Shunpei
AU - Tahara, Yu
AU - Sasaki, Hiroyuki
AU - Hamaguchi, Yutaro
AU - Kuriki, Daisuke
AU - Ishikawa, Ryosuke
AU - Ishigooka, Jun
AU - Shibata, Shigenobu
PY - 2014
Y1 - 2014
N2 - Circadian rhythms are related to various psychiatric disorders. Recently, antipsychotics, including quetiapine (QTP), have been accepted as potential therapeutic agents for the treatment of depression, but its mechanism remains poorly understood. In this study, we examined clock gene fluctuation patterns in QTP-treated mice. QTP significantly increased Per2 mRNA at ZT12 and Per1 and Per2 expression at ZT18 in the amygdala. There were significant differences between the control and QTP groups in the cross-time effects of Per2 mRNA expression in the amygdala. Our findings suggest that QTP possibly acts on the circadian system, which then induces changes in mood symptoms.
AB - Circadian rhythms are related to various psychiatric disorders. Recently, antipsychotics, including quetiapine (QTP), have been accepted as potential therapeutic agents for the treatment of depression, but its mechanism remains poorly understood. In this study, we examined clock gene fluctuation patterns in QTP-treated mice. QTP significantly increased Per2 mRNA at ZT12 and Per1 and Per2 expression at ZT18 in the amygdala. There were significant differences between the control and QTP groups in the cross-time effects of Per2 mRNA expression in the amygdala. Our findings suggest that QTP possibly acts on the circadian system, which then induces changes in mood symptoms.
KW - Clock gene
KW - Depression
KW - Quetiapine
UR - http://www.scopus.com/inward/record.url?scp=84904680142&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84904680142&partnerID=8YFLogxK
U2 - 10.1254/jphs.14071SC
DO - 10.1254/jphs.14071SC
M3 - Article
C2 - 24965164
AN - SCOPUS:84904680142
SN - 1347-8613
VL - 125
SP - 329
EP - 332
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
IS - 3
ER -