Effect of stimulation of locus coeruleus on the evoked potential in the amygdala in rats

Ryozo Oishi; Shigenori Watanabe; Shigenobu Shibata; Showa Ueki; Kenji Ohmori

doi:10.1254/jjp.29.105

Effect of stimulation of locus coeruleus on the evoked potential in the amygdala in rats

Ryozo Oishi, Shigenori Watanabe, Shigenobu Shibata, Showa Ueki, Kenji Ohmori

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Effects of stimulation of the locus coeruleus (LC) on evoked potential in the medial amygdala elicited by stimulation of the olfactory bulb (OB-AME potential) were studied in gallamine-immobilized rats. The amplitude of the OB-AME potential was inhibited 27.5%. by the conditioning stimulation of LC delivered 30 msec before the test stimulation. The inhibitory effect of LC was reduced by propranolol 5 mg/kg i.p., but not by phentolamine 10 mg/kg i.p․ This effect was also reduced by tetrabenazine 10 mg/kg i.p.․ Methamphetamine 5 mg/kg i.p. produced considerable potentiation of the LC inhibitory effect and a reduction of the OB-AME potential itself. These results suggest that the LC plays an inhibitory role in the electrical activity of the medial amygdala.

Original language	English
Pages (from-to)	105-111
Number of pages	7
Journal	Journal of Pharmacological Sciences
Volume	29
Issue number	1
DOIs	https://doi.org/10.1254/jjp.29.105
Publication status	Published - 1979
Externally published	Yes

ASJC Scopus subject areas

Pharmacology

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title = "Effect of stimulation of locus coeruleus on the evoked potential in the amygdala in rats",

abstract = "Effects of stimulation of the locus coeruleus (LC) on evoked potential in the medial amygdala elicited by stimulation of the olfactory bulb (OB-AME potential) were studied in gallamine-immobilized rats. The amplitude of the OB-AME potential was inhibited 27.5%. by the conditioning stimulation of LC delivered 30 msec before the test stimulation. The inhibitory effect of LC was reduced by propranolol 5 mg/kg i.p., but not by phentolamine 10 mg/kg i.p․ This effect was also reduced by tetrabenazine 10 mg/kg i.p.․ Methamphetamine 5 mg/kg i.p. produced considerable potentiation of the LC inhibitory effect and a reduction of the OB-AME potential itself. These results suggest that the LC plays an inhibitory role in the electrical activity of the medial amygdala.",

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AU - Oishi, Ryozo

AU - Watanabe, Shigenori

AU - Shibata, Shigenobu

AU - Ueki, Showa

AU - Ohmori, Kenji

PY - 1979

Y1 - 1979

N2 - Effects of stimulation of the locus coeruleus (LC) on evoked potential in the medial amygdala elicited by stimulation of the olfactory bulb (OB-AME potential) were studied in gallamine-immobilized rats. The amplitude of the OB-AME potential was inhibited 27.5%. by the conditioning stimulation of LC delivered 30 msec before the test stimulation. The inhibitory effect of LC was reduced by propranolol 5 mg/kg i.p., but not by phentolamine 10 mg/kg i.p․ This effect was also reduced by tetrabenazine 10 mg/kg i.p.․ Methamphetamine 5 mg/kg i.p. produced considerable potentiation of the LC inhibitory effect and a reduction of the OB-AME potential itself. These results suggest that the LC plays an inhibitory role in the electrical activity of the medial amygdala.

AB - Effects of stimulation of the locus coeruleus (LC) on evoked potential in the medial amygdala elicited by stimulation of the olfactory bulb (OB-AME potential) were studied in gallamine-immobilized rats. The amplitude of the OB-AME potential was inhibited 27.5%. by the conditioning stimulation of LC delivered 30 msec before the test stimulation. The inhibitory effect of LC was reduced by propranolol 5 mg/kg i.p., but not by phentolamine 10 mg/kg i.p․ This effect was also reduced by tetrabenazine 10 mg/kg i.p.․ Methamphetamine 5 mg/kg i.p. produced considerable potentiation of the LC inhibitory effect and a reduction of the OB-AME potential itself. These results suggest that the LC plays an inhibitory role in the electrical activity of the medial amygdala.

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Effect of stimulation of locus coeruleus on the evoked potential in the amygdala in rats

Abstract

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