Effect of the surfactant pluronic on the stability of lipid-stabilized perfluorocarbon nanobubbles

Lenitza Nieves; Christopher Hernandez; Jacob Lilly; Joey Mangadlao; Rigoberto Advincula; Agata Exner

doi:10.1109/ULTSYM.2017.8092148

Effect of the surfactant pluronic on the stability of lipid-stabilized perfluorocarbon nanobubbles

Lenitza Nieves, Christopher Hernandez, Jacob Lilly, Joey Mangadlao, Rigoberto Advincula, Agata Exner

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

Microbubble (MB) contrast agents are widely used in diagnostic and therapeutic ultrasound (US) applications. However, due to their 1-10 μm size range, MBs have limited use in cancer detection and treatment. To expand contrast enhanced US capabilities, we have developed sub-micron contrast agents, nanobubbles (NB), via the addition of Pluronic, a nonionic triblock copolymer surfactant, to the phospholipid shell stabilizing perfluoropropane (C3F8) gas (Fig 1A). NBs, with diameter of ∼200nm, can take advantage of the EPR effect, extravasate the leaky tumor vasculature and accumulate in tumors. Prior work has shown that bubble echogenicity and stability are, in part, dependent on the surface tension of the stabilizing shell. In this study, we evaluate the effect of Pluronic on surface tension of the lipid films and how its presence in the NB shell affects echogenicity and signal decay at clinically-relevant imaging frequencies.

Original language	English
Title of host publication	2017 IEEE International Ultrasonics Symposium, IUS 2017
Publisher	IEEE Computer Society
ISBN (Electronic)	9781538633830
DOIs	https://doi.org/10.1109/ULTSYM.2017.8092148
Publication status	Published - 2017 Oct 31
Event	2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States Duration: 2017 Sept 6 → 2017 Sept 9

Other

Other	2017 IEEE International Ultrasonics Symposium, IUS 2017
Country/Territory	United States
City	Washington
Period	17/9/6 → 17/9/9

ASJC Scopus subject areas

Acoustics and Ultrasonics

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/ULTSYM.2017.8092148

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Nieves, L, Hernandez, C, Lilly, J, Mangadlao, J, Advincula, R & Exner, A 2017, Effect of the surfactant pluronic on the stability of lipid-stabilized perfluorocarbon nanobubbles. in 2017 IEEE International Ultrasonics Symposium, IUS 2017., 8092148, IEEE Computer Society, 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States, 17/9/6. https://doi.org/10.1109/ULTSYM.2017.8092148

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abstract = "Microbubble (MB) contrast agents are widely used in diagnostic and therapeutic ultrasound (US) applications. However, due to their 1-10 μm size range, MBs have limited use in cancer detection and treatment. To expand contrast enhanced US capabilities, we have developed sub-micron contrast agents, nanobubbles (NB), via the addition of Pluronic, a nonionic triblock copolymer surfactant, to the phospholipid shell stabilizing perfluoropropane (C3F8) gas (Fig 1A). NBs, with diameter of ∼200nm, can take advantage of the EPR effect, extravasate the leaky tumor vasculature and accumulate in tumors. Prior work has shown that bubble echogenicity and stability are, in part, dependent on the surface tension of the stabilizing shell. In this study, we evaluate the effect of Pluronic on surface tension of the lipid films and how its presence in the NB shell affects echogenicity and signal decay at clinically-relevant imaging frequencies.",

author = "Lenitza Nieves and Christopher Hernandez and Jacob Lilly and Joey Mangadlao and Rigoberto Advincula and Agata Exner",

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doi = "10.1109/ULTSYM.2017.8092148",

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AU - Nieves, Lenitza

AU - Hernandez, Christopher

AU - Lilly, Jacob

AU - Mangadlao, Joey

AU - Advincula, Rigoberto

AU - Exner, Agata

PY - 2017/10/31

Y1 - 2017/10/31

N2 - Microbubble (MB) contrast agents are widely used in diagnostic and therapeutic ultrasound (US) applications. However, due to their 1-10 μm size range, MBs have limited use in cancer detection and treatment. To expand contrast enhanced US capabilities, we have developed sub-micron contrast agents, nanobubbles (NB), via the addition of Pluronic, a nonionic triblock copolymer surfactant, to the phospholipid shell stabilizing perfluoropropane (C3F8) gas (Fig 1A). NBs, with diameter of ∼200nm, can take advantage of the EPR effect, extravasate the leaky tumor vasculature and accumulate in tumors. Prior work has shown that bubble echogenicity and stability are, in part, dependent on the surface tension of the stabilizing shell. In this study, we evaluate the effect of Pluronic on surface tension of the lipid films and how its presence in the NB shell affects echogenicity and signal decay at clinically-relevant imaging frequencies.

AB - Microbubble (MB) contrast agents are widely used in diagnostic and therapeutic ultrasound (US) applications. However, due to their 1-10 μm size range, MBs have limited use in cancer detection and treatment. To expand contrast enhanced US capabilities, we have developed sub-micron contrast agents, nanobubbles (NB), via the addition of Pluronic, a nonionic triblock copolymer surfactant, to the phospholipid shell stabilizing perfluoropropane (C3F8) gas (Fig 1A). NBs, with diameter of ∼200nm, can take advantage of the EPR effect, extravasate the leaky tumor vasculature and accumulate in tumors. Prior work has shown that bubble echogenicity and stability are, in part, dependent on the surface tension of the stabilizing shell. In this study, we evaluate the effect of Pluronic on surface tension of the lipid films and how its presence in the NB shell affects echogenicity and signal decay at clinically-relevant imaging frequencies.

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M3 - Conference contribution

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BT - 2017 IEEE International Ultrasonics Symposium, IUS 2017

PB - IEEE Computer Society

T2 - 2017 IEEE International Ultrasonics Symposium, IUS 2017

Y2 - 6 September 2017 through 9 September 2017

ER -

Effect of the surfactant pluronic on the stability of lipid-stabilized perfluorocarbon nanobubbles

Abstract

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