TY - JOUR
T1 - Effects of aerobic exercise training on circulating angiopoietin-like protein 2 in overweight and obese men
T2 - a pilot study
AU - Park, Jiyeon
AU - Kosaki, Keisei
AU - Myoenzono, Kanae
AU - Choi, Youngju
AU - Tsujimoto, Takehiko
AU - Shimojo, Nobutake
AU - Maeda, Seiji
N1 - Funding Information:
We are grateful to members of our laboratory (University of Tsukuba) for their technical assistance and helpful discussion.
Publisher Copyright:
© 2022 The Author(s).
PY - 2022
Y1 - 2022
N2 - Background and objective: Angiopoietin-like protein 2 (ANGPTL2) is a pro-inflammatory adipokine that is upregulated in obesity and plays a role in the progression of cardiometabolic diseases, including diabetes and atherosclerosis. Aerobic exercise is one of the effective strategies for reducing the levels of various pro-inflammatory biomolecules in obese individuals. However, the effects of aerobic exercise training on circulating ANGPTL2 levels in obese individuals remain unclear. The objective of this study was to investigate the effect of aerobic exercise training on serum ANGPTL2 levels in overweight and obese men. Material and methods: Twenty overweight and obese men (age, 49 ± 10 years; body mass index, 27.4 ± 2.2 kg/m2) completed a 12-week aerobic exercise training program (60–85% Heart ratemax, 40–60 min/day, 3 days/week). Before and after the exercise program, serum ANGPTL2 levels were measured using the enzyme-linked immunosorbent assay. Daily step counts and the different physical activities based on the intensity were assessed using a triaxial accelerometer. Results: Serum ANGPTL2 levels were significantly decreased after the 12-week aerobic exercise training program ((3.0 ± 0.6) vs. (2.7 ± 0.7) ng/mL, P < 0.05). Daily step counts ((8362 ± 4551) vs. (10357 ± 3168) steps/day, P < 0.05) and moderate- to vigorous-intensity physical activity (MVPA) time ((58 ± 45) vs. (76 ± 37) min/day, P < 0.001) were significantly increased after the exercise intervention. The changes in serum ANGPTL2 levels were negatively correlated with corresponding changes in daily step counts (partial r = –0.49, P < 0.05) and MVPA time (partial r = –0.47, P < 0.05) after adjustment for age and accelerometer wear time. Conlcusion: These findings collectively suggest that aerobic exercise training, in particular an increase in MVPA, can be associated with decreased circulating levels of ANGPTL2 in overweight and obese men.
AB - Background and objective: Angiopoietin-like protein 2 (ANGPTL2) is a pro-inflammatory adipokine that is upregulated in obesity and plays a role in the progression of cardiometabolic diseases, including diabetes and atherosclerosis. Aerobic exercise is one of the effective strategies for reducing the levels of various pro-inflammatory biomolecules in obese individuals. However, the effects of aerobic exercise training on circulating ANGPTL2 levels in obese individuals remain unclear. The objective of this study was to investigate the effect of aerobic exercise training on serum ANGPTL2 levels in overweight and obese men. Material and methods: Twenty overweight and obese men (age, 49 ± 10 years; body mass index, 27.4 ± 2.2 kg/m2) completed a 12-week aerobic exercise training program (60–85% Heart ratemax, 40–60 min/day, 3 days/week). Before and after the exercise program, serum ANGPTL2 levels were measured using the enzyme-linked immunosorbent assay. Daily step counts and the different physical activities based on the intensity were assessed using a triaxial accelerometer. Results: Serum ANGPTL2 levels were significantly decreased after the 12-week aerobic exercise training program ((3.0 ± 0.6) vs. (2.7 ± 0.7) ng/mL, P < 0.05). Daily step counts ((8362 ± 4551) vs. (10357 ± 3168) steps/day, P < 0.05) and moderate- to vigorous-intensity physical activity (MVPA) time ((58 ± 45) vs. (76 ± 37) min/day, P < 0.001) were significantly increased after the exercise intervention. The changes in serum ANGPTL2 levels were negatively correlated with corresponding changes in daily step counts (partial r = –0.49, P < 0.05) and MVPA time (partial r = –0.47, P < 0.05) after adjustment for age and accelerometer wear time. Conlcusion: These findings collectively suggest that aerobic exercise training, in particular an increase in MVPA, can be associated with decreased circulating levels of ANGPTL2 in overweight and obese men.
KW - Aerobic exercise;
KW - Angiopoietin-like protein 2;
KW - Inflammation;
KW - Obesity
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U2 - 10.31083/jomh.2021.121
DO - 10.31083/jomh.2021.121
M3 - Article
AN - SCOPUS:85127548888
SN - 1875-6867
VL - 18
JO - Journal of Men's Health and Gender
JF - Journal of Men's Health and Gender
IS - 3
M1 - 053
ER -