Abstract
The effect of an upstream DNA curvature on the strength of the herpes simplex virus thymidine kinase (TK) promoter was investigated by employing luciferase assay. A set of double-stranded oligonucleotides, each with an unique DNA configuration, were synthesized and substituted into an upstream region of the promoter. It was revealed from the assay that both plane and space curves exerted a negative influence upon the strength of the promoter.
| Original language | English |
|---|---|
| Pages (from-to) | 67-68 |
| Number of pages | 2 |
| Journal | Nucleic acids symposium series |
| Issue number | 34 |
| Publication status | Published - 1995 |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)