TY - JOUR
T1 - Effects of curcumin intake and aerobic exercise training on arterial compliance in postmenopausal women
AU - Akazawa, Nobuhiko
AU - Choi, Youngju
AU - Miyaki, Asako
AU - Tanabe, Yoko
AU - Sugawara, Jun
AU - Ajisaka, Ryuichi
AU - Maeda, Seiji
N1 - Funding Information:
This work was supported by Grants-in-Aid for Scientific Research 21300234 and 2160179 from Japan Society for the Promotion of Science .
PY - 2013/3
Y1 - 2013/3
N2 - Background: Reduction in arterial compliance with aging increases the risk of cardiovascular disease. Lifestyle modification, particularly aerobic exercise and dietary modification, has a favorable effect on vascular aging. Curcumin, a major component of turmeric, is an anti-inflammatory agent. Therefore, it is plausible to hypothesize that curcumin improves arterial compliance. We investigated the effects of curcumin ingestion alone and in combination with aerobic exercise training on arterial compliance in postmenopausal women. Methods: A total of 51 postmenopausal women were assigned to 4 groups: placebo, curcumin, exercise and placebo (Ex + placebo), and exercise and curcumin (Ex + curcumin). Curcumin or placebo was ingested orally for 8 weeks. The exercise groups underwent moderate aerobic exercise training for 8 weeks. Results: Carotid arterial compliance increased significantly in the curcumin, Ex + placebo, and Ex + curcumin groups, whereas no such changes were observed in the placebo control group. The magnitude of increases in carotid arterial compliance was the greatest in the Ex + curcumin group. Conclusion: We concluded that curcumin ingestion improves carotid arterial compliance and that the combination of curcumin and aerobic exercise training was more efficacious in increasing central arterial compliance than either of these treatments alone in postmenopausal women.
AB - Background: Reduction in arterial compliance with aging increases the risk of cardiovascular disease. Lifestyle modification, particularly aerobic exercise and dietary modification, has a favorable effect on vascular aging. Curcumin, a major component of turmeric, is an anti-inflammatory agent. Therefore, it is plausible to hypothesize that curcumin improves arterial compliance. We investigated the effects of curcumin ingestion alone and in combination with aerobic exercise training on arterial compliance in postmenopausal women. Methods: A total of 51 postmenopausal women were assigned to 4 groups: placebo, curcumin, exercise and placebo (Ex + placebo), and exercise and curcumin (Ex + curcumin). Curcumin or placebo was ingested orally for 8 weeks. The exercise groups underwent moderate aerobic exercise training for 8 weeks. Results: Carotid arterial compliance increased significantly in the curcumin, Ex + placebo, and Ex + curcumin groups, whereas no such changes were observed in the placebo control group. The magnitude of increases in carotid arterial compliance was the greatest in the Ex + curcumin group. Conclusion: We concluded that curcumin ingestion improves carotid arterial compliance and that the combination of curcumin and aerobic exercise training was more efficacious in increasing central arterial compliance than either of these treatments alone in postmenopausal women.
KW - Arterial stiffness
KW - Lifestyle modification
KW - Physical activity
KW - Turmeric
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U2 - 10.1016/j.artres.2012.09.003
DO - 10.1016/j.artres.2012.09.003
M3 - Article
AN - SCOPUS:84874331175
SN - 1872-9312
VL - 7
SP - 67
EP - 72
JO - Artery Research
JF - Artery Research
IS - 1
ER -
