Effects of daily physical activity on insulin action in the elderly

K. Yamanouchi, H. Nakajima, T. Shinozaki, K. Chikada, K. Kato, Y. Oshida, I. Osawa, J. Sato, Y. Sato*, Mitsuru Higuchi, S. Kobayashi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


The effects of daily physical activity on peripheral insulin action were investigated in aged individuals. Glucose infusion rates (GIR) during the euglycemic insulin clamp procedure in aged bedridden, aged controls, and aged athletes were compared with those in young controls and young athletes at insulin infusion rates of 40 and 400 mU · m-2 · min-1 to estimate insulin action at physiological and maximal insulin concentrations, respectively. At both insulin infusion rates, GIR was significantly higher in aged athletes and significantly lower in aged bedridden subjects than in aged controls. Although there was no statistical difference in GIR at 400 mU · m-2 · min-1 between young athletes and young controls, GIR at 40 mU · m-2 · min-1 was higher in young athletes than in young controls. Comparison of the aged and young groups showed that although GIR at 400 mU · m-2 · min-1 was significantly lower in aged controls than in young controls, there was no significant difference between the aged athletes and the young athletes. We conclude that insulin responsiveness (insulin action at the postreceptor binding site) may decrease with the aging process and may be further affected by physical inactivity. Although physical training may improve insulin responsiveness in aged individuals up to levels similar to those in young athletes, physical training in young individuals may improve only insulin sensitivity.

Original languageEnglish
Pages (from-to)2241-2245
Number of pages5
JournalJournal of Applied Physiology
Issue number6
Publication statusPublished - 1992
Externally publishedYes


  • aged individuals
  • euglycemic clamp
  • insulin responsiveness
  • insulin sensitivity
  • physical training

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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