Effects of dibutyryl cyclic adenosine monophosphate and dibutyryl cyclic guanosine monophosphate on neuron activity of suprachiasmatic nucleus in rat hypothalamic slice preparation

Shyh Yuh Liou; Shigenobu Shibata; Akiko Shiratsuchi; Showa Ueki

doi:10.1016/0304-3940(86)90333-2

Effects of dibutyryl cyclic adenosine monophosphate and dibutyryl cyclic guanosine monophosphate on neuron activity of suprachiasmatic nucleus in rat hypothalamic slice preparation

Shyh Yuh Liou^*, Shigenobu Shibata, Akiko Shiratsuchi, Showa Ueki

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

In order to elucidate the role of cyclic nucleotides in the suprachiasmatic nucleus, we examined the effect of dibutyryl cyclic AMP (c-AMP) and dibutyryl cyclic GMP (c-GMP) on single neuronal activity of the suprachiasmatic nucleus of the rat. A hypothalamic slice about 300 μm thick, including the suprachiasmatic nucleus, was cut coronally using a vibratome. By means of bath- as well as iontophoretic application, c-AMP and c-GMP caused mainly an inhibition and facilitation in suprachiasmatic neuronal activity, respectively. The present results suggest that c-AMP and c-GMP play an important role in regulation of suprachiasmatic neuronal activity as a second messenger and that these two nucleotides may function as a reciprocal messenger.

Original language	English
Pages (from-to)	339-343
Number of pages	5
Journal	Neuroscience Letters
Volume	67
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(86)90333-2
Publication status	Published - 1986 Jun 30
Externally published	Yes

Keywords

cyclic nucleotide
electrophysiology
rat
single neuron
suprachiasmatic nucleus

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(86)90333-2

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Effects of dibutyryl cyclic adenosine monophosphate and dibutyryl cyclic guanosine monophosphate on neuron activity of suprachiasmatic nucleus in rat hypothalamic slice preparation. / Liou, Shyh Yuh; Shibata, Shigenobu; Shiratsuchi, Akiko et al.
In: Neuroscience Letters, Vol. 67, No. 3, 30.06.1986, p. 339-343.

Research output: Contribution to journal › Article › peer-review

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abstract = "In order to elucidate the role of cyclic nucleotides in the suprachiasmatic nucleus, we examined the effect of dibutyryl cyclic AMP (c-AMP) and dibutyryl cyclic GMP (c-GMP) on single neuronal activity of the suprachiasmatic nucleus of the rat. A hypothalamic slice about 300 μm thick, including the suprachiasmatic nucleus, was cut coronally using a vibratome. By means of bath- as well as iontophoretic application, c-AMP and c-GMP caused mainly an inhibition and facilitation in suprachiasmatic neuronal activity, respectively. The present results suggest that c-AMP and c-GMP play an important role in regulation of suprachiasmatic neuronal activity as a second messenger and that these two nucleotides may function as a reciprocal messenger.",

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AU - Liou, Shyh Yuh

AU - Shibata, Shigenobu

AU - Shiratsuchi, Akiko

AU - Ueki, Showa

PY - 1986/6/30

Y1 - 1986/6/30

N2 - In order to elucidate the role of cyclic nucleotides in the suprachiasmatic nucleus, we examined the effect of dibutyryl cyclic AMP (c-AMP) and dibutyryl cyclic GMP (c-GMP) on single neuronal activity of the suprachiasmatic nucleus of the rat. A hypothalamic slice about 300 μm thick, including the suprachiasmatic nucleus, was cut coronally using a vibratome. By means of bath- as well as iontophoretic application, c-AMP and c-GMP caused mainly an inhibition and facilitation in suprachiasmatic neuronal activity, respectively. The present results suggest that c-AMP and c-GMP play an important role in regulation of suprachiasmatic neuronal activity as a second messenger and that these two nucleotides may function as a reciprocal messenger.

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Effects of dibutyryl cyclic adenosine monophosphate and dibutyryl cyclic guanosine monophosphate on neuron activity of suprachiasmatic nucleus in rat hypothalamic slice preparation

Abstract

Keywords

ASJC Scopus subject areas

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