Effects of dibutyryl cyclic adenosine monophosphate and dibutyryl cyclic guanosine monophosphate on neuron activity of suprachiasmatic nucleus in rat hypothalamic slice preparation

Shyh Yuh Liou*, Shigenobu Shibata, Akiko Shiratsuchi, Showa Ueki

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

In order to elucidate the role of cyclic nucleotides in the suprachiasmatic nucleus, we examined the effect of dibutyryl cyclic AMP (c-AMP) and dibutyryl cyclic GMP (c-GMP) on single neuronal activity of the suprachiasmatic nucleus of the rat. A hypothalamic slice about 300 μm thick, including the suprachiasmatic nucleus, was cut coronally using a vibratome. By means of bath- as well as iontophoretic application, c-AMP and c-GMP caused mainly an inhibition and facilitation in suprachiasmatic neuronal activity, respectively. The present results suggest that c-AMP and c-GMP play an important role in regulation of suprachiasmatic neuronal activity as a second messenger and that these two nucleotides may function as a reciprocal messenger.

Original languageEnglish
Pages (from-to)339-343
Number of pages5
JournalNeuroscience Letters
Volume67
Issue number3
DOIs
Publication statusPublished - 1986 Jun 30
Externally publishedYes

Keywords

  • cyclic nucleotide
  • electrophysiology
  • rat
  • single neuron
  • suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

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