TY - JOUR
T1 - Effects of dietary modification with weight loss on central blood pressure during oral glucose tolerance test in overweight/obese men
AU - Yoshikawa, Toru
AU - Kumagai, Hiroshi
AU - Myoenzono, Kanae
AU - Zempo-Miyaki, Asako
AU - Tsujimoto, Takehiko
AU - Tanaka, Kiyoji
AU - Maeda, Seiji
N1 - Funding Information:
This study was supported by a Grant-in-Aid for JSPS Research Fellow ( 15J00840 ), Tokyo, Japan. We are grateful to Dr. Nobuhiko Akazawa, Mr. Koichiro Tanahashi, Mr. Satoshi Oikawa, Mr. Kaname Tagawa, Mr. Keisei Kosaki, and Ms. Yuriko Sawano for their technical assistance and helpful discussions. We would also like to thank the research members of K.T.’s laboratory for their assistance in conducting the diet program.
Publisher Copyright:
© 2017 Association for Research into Arterial Structure and Physiology
PY - 2017/12
Y1 - 2017/12
N2 - Background Postprandial regulation of central systolic blood pressure (cSBP) is impaired by obesity-related disorders. The present study aimed to examine the effect of hypocaloric diet intervention on cSBP when performing oral glucose tolerance test (OGTT) in overweight/obese men and explore its mechanism. Methods Fifteen overweight/obese men (mean ± SD; age, 52 ± 10 years; BMI, 29.1 ± 2.3 kg/m2) completed a 12-week dietary modification program (group lectures and individual counseling conducted 8 times in 12 weeks, 1680 kcal/day). Before and after the program, body mass, daily intakes of total energy and major macronutrients, serum lipid profiles, and homeostasis model assessment for insulin resistance (HOMA-IR) were measured, and plasma glucose, serum insulin, and cSBP (i.e., radial second systolic pressure) were assessed when fasting and at 60 min and 120 min after 75 g oral glucose loading. Results The 12-week program led to successful weight loss (−10.1 kg or −12.1%) with significant reductions in the daily intakes of total energy and major macronutrients. Consequently, low-density lipoprotein cholesterol, triglycerides, HOMA-IR (2.1 ± 1.3 to 0.8 ± 0.3, p < 0.01), and glucose and insulin during OGTT were substantially decreased after 12 weeks. The diet program had also resulted in significantly reduced 2-h averaged cSBP during OGTT (111 ± 11 to 103 ± 10 mmHg, p < 0.01). There was a significant correlation between the changes from baseline in both HOMA-IR and 2-h averaged cSBP (rs = 0.69, p < 0.01). Conclusions The current results suggest that the dietary modification–induced improvement in insulin resistance has contributed to a significant reduction in cSBP during OGTT in overweight/obese men.
AB - Background Postprandial regulation of central systolic blood pressure (cSBP) is impaired by obesity-related disorders. The present study aimed to examine the effect of hypocaloric diet intervention on cSBP when performing oral glucose tolerance test (OGTT) in overweight/obese men and explore its mechanism. Methods Fifteen overweight/obese men (mean ± SD; age, 52 ± 10 years; BMI, 29.1 ± 2.3 kg/m2) completed a 12-week dietary modification program (group lectures and individual counseling conducted 8 times in 12 weeks, 1680 kcal/day). Before and after the program, body mass, daily intakes of total energy and major macronutrients, serum lipid profiles, and homeostasis model assessment for insulin resistance (HOMA-IR) were measured, and plasma glucose, serum insulin, and cSBP (i.e., radial second systolic pressure) were assessed when fasting and at 60 min and 120 min after 75 g oral glucose loading. Results The 12-week program led to successful weight loss (−10.1 kg or −12.1%) with significant reductions in the daily intakes of total energy and major macronutrients. Consequently, low-density lipoprotein cholesterol, triglycerides, HOMA-IR (2.1 ± 1.3 to 0.8 ± 0.3, p < 0.01), and glucose and insulin during OGTT were substantially decreased after 12 weeks. The diet program had also resulted in significantly reduced 2-h averaged cSBP during OGTT (111 ± 11 to 103 ± 10 mmHg, p < 0.01). There was a significant correlation between the changes from baseline in both HOMA-IR and 2-h averaged cSBP (rs = 0.69, p < 0.01). Conclusions The current results suggest that the dietary modification–induced improvement in insulin resistance has contributed to a significant reduction in cSBP during OGTT in overweight/obese men.
KW - Aortic pressure
KW - Energy restriction
KW - Excess weight
KW - Glucose challenge
KW - Insulin sensitivity
KW - Weight reduction
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U2 - 10.1016/j.artres.2017.10.199
DO - 10.1016/j.artres.2017.10.199
M3 - Article
AN - SCOPUS:85032711319
SN - 1872-9312
VL - 20
SP - 27
EP - 34
JO - Artery Research
JF - Artery Research
ER -
