Effects of fenugreek seed extract in obese mice fed a high-fat diet

Toshiaki Handa, Kohji Yamaguchi, Yoshikatsu Sono, Kazunaga Yazawa*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)


It was found that fenugreek seed extract reduced the body weight gain induced by a high-fat diet in obese mice. The extract decreased plasma triglyceride gain induced by oil administration. The major component of the extract, 4-hydroxyisoleucine, also decreased plasma triglyceride gain. Consequently, fenugreek seed extract is expected to prevent the obesity induced by a high-fat diet.

Original languageEnglish
Pages (from-to)1186-1188
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Issue number6
Publication statusPublished - 2005 Jun
Externally publishedYes


  • 4-hydroxyisoleucine
  • Fenugreek
  • High-fat diet
  • Obesity
  • Triglyceride

ASJC Scopus subject areas

  • Bioengineering
  • Biotechnology
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry (miscellaneous)
  • Applied Microbiology and Biotechnology
  • Food Science


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