Effects of intrinsic noise in temperature-compensated models for circadian rhythms

Sho Ichikawa*, Yohei Ito, Gen Kurosawa, Kenko Uchida

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference contribution


    Circadian rhythms, which are observed in most of organisms, e.g. bacteria, fungi, plants, and animals, are self-sustained oscillations with about 24 hours period and a remarkable temperature compensation property. By using the temperature-compensated and robust temperature-compensated deterministic models for circadian rhythms, we perform the stochastic simulations based on the Gillespie's method by changing temperature over a wide range, and discuss how the deterministic temperature compensation properties fluctuate over the range of temperature in the stochastic setting reflecting the intrinsically noisy environments. In order to strengthen the inference from the stochastic simulations, we also execute a qualitative analysis based on the linear noise approximation.

    Original languageEnglish
    Title of host publicationICCAS-SICE 2009 - ICROS-SICE International Joint Conference 2009, Proceedings
    Number of pages6
    Publication statusPublished - 2009
    EventICROS-SICE International Joint Conference 2009, ICCAS-SICE 2009 - Fukuoka
    Duration: 2009 Aug 182009 Aug 21


    OtherICROS-SICE International Joint Conference 2009, ICCAS-SICE 2009


    • Circadian rhythm
    • Intrinsic noise
    • Temperature compensation

    ASJC Scopus subject areas

    • Information Systems
    • Control and Systems Engineering
    • Industrial and Manufacturing Engineering


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