Effects of life events and stress on neutrophil functions in elderly men

Kazumasa Tsukamoto*, Kazuhiko Machida

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Background: Psychological stress or life events might significantly decrease neutrophil function in elderly individuals and lead to infectious diseases. However, relationships between these factors have not been examined in detail.We investigated the relationships between neutrophil function measured using the nitroblue tetrazolium (NBT) reduction test and measurements of psychological stress and life events among 81 men aged over 60 years.Results: The numbers and scores for life events were significantly higher (p < 0.01, respectively) in a group with values reflecting phagocytosis below the median than in a control group.Conclusions: Chronic psychological stress due to life events decreases neutrophil functions among elderly men.

Original languageEnglish
Article number13
JournalImmunity and Ageing
Publication statusPublished - 2012 Jun 9


  • Immunity
  • Immunosenescence
  • Phagocytosis

ASJC Scopus subject areas

  • Immunology
  • Ageing


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