Effects of life events and stress on neutrophil functions in elderly men

Kazumasa Tsukamoto; Kazuhiko Machida

doi:10.1186/1742-4933-9-13

Effects of life events and stress on neutrophil functions in elderly men

Kazumasa Tsukamoto^*, Kazuhiko Machida

^*Corresponding author for this work

Waseda University

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Background: Psychological stress or life events might significantly decrease neutrophil function in elderly individuals and lead to infectious diseases. However, relationships between these factors have not been examined in detail.We investigated the relationships between neutrophil function measured using the nitroblue tetrazolium (NBT) reduction test and measurements of psychological stress and life events among 81 men aged over 60 years.Results: The numbers and scores for life events were significantly higher (p < 0.01, respectively) in a group with values reflecting phagocytosis below the median than in a control group.Conclusions: Chronic psychological stress due to life events decreases neutrophil functions among elderly men.

Original language	English
Article number	13
Journal	Immunity and Ageing
Volume	9
DOIs	https://doi.org/10.1186/1742-4933-9-13
Publication status	Published - 2012 Jun 9

Keywords

Immunity
Immunosenescence
Phagocytosis

ASJC Scopus subject areas

Immunology
Ageing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1742-4933-9-13

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abstract = "Background: Psychological stress or life events might significantly decrease neutrophil function in elderly individuals and lead to infectious diseases. However, relationships between these factors have not been examined in detail.We investigated the relationships between neutrophil function measured using the nitroblue tetrazolium (NBT) reduction test and measurements of psychological stress and life events among 81 men aged over 60 years.Results: The numbers and scores for life events were significantly higher (p < 0.01, respectively) in a group with values reflecting phagocytosis below the median than in a control group.Conclusions: Chronic psychological stress due to life events decreases neutrophil functions among elderly men.",

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AU - Tsukamoto, Kazumasa

AU - Machida, Kazuhiko

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N2 - Background: Psychological stress or life events might significantly decrease neutrophil function in elderly individuals and lead to infectious diseases. However, relationships between these factors have not been examined in detail.We investigated the relationships between neutrophil function measured using the nitroblue tetrazolium (NBT) reduction test and measurements of psychological stress and life events among 81 men aged over 60 years.Results: The numbers and scores for life events were significantly higher (p < 0.01, respectively) in a group with values reflecting phagocytosis below the median than in a control group.Conclusions: Chronic psychological stress due to life events decreases neutrophil functions among elderly men.

AB - Background: Psychological stress or life events might significantly decrease neutrophil function in elderly individuals and lead to infectious diseases. However, relationships between these factors have not been examined in detail.We investigated the relationships between neutrophil function measured using the nitroblue tetrazolium (NBT) reduction test and measurements of psychological stress and life events among 81 men aged over 60 years.Results: The numbers and scores for life events were significantly higher (p < 0.01, respectively) in a group with values reflecting phagocytosis below the median than in a control group.Conclusions: Chronic psychological stress due to life events decreases neutrophil functions among elderly men.

KW - Immunity

KW - Immunosenescence

KW - Phagocytosis

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Effects of life events and stress on neutrophil functions in elderly men

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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