TY - JOUR
T1 - Effects of prolyl endopeptidase inhibitors and neuropeptides on delayed neuronal death in rats
AU - Shishido, Yoshiyuki
AU - Furushiro, Masayoshi
AU - Tanabe, Shuichi
AU - Shibata, Shigenobu
AU - Hashimoto, Shusuke
AU - Yokokura, Teruo
PY - 1999/5/14
Y1 - 1999/5/14
N2 - We investigated the effects of the prolyl endopeptidase inhibitors 1-[1-(Benzyloxycarbonyl)-l-prolyl]prolinal (Z-Pro-Prolinal) and N-benzyloxycarbonyl-thioprolyl-thioprolinal-dimethylacetal (ZTTA) on delayed neuronal death induced by four-vessel-occlusion transient ischemia in rats. We also examined the effects of [pGlu4, Cyt6, Arg8]vasopressin (vasopressin-(4-9)) and thyrotropin-releasing hormone (TRH) on the delayed neuronal death. Furthermore, we investigated the role of vasopressin receptors in the effects of vasopressin and prolyl endopeptidase inhibitors. Z-Pro-Prolinal, vasopressin-(4-9) and TRH protected pyramidal cells in the CA1 subfield of the rat hippocampus from delayed neuronal death after 10-min ischemia. The effect of vasopressin-(4-9) was abolished by vasopressin receptor antagonists. The effect of Z-Pro-Prolinal was also abrogated by the antagonists. These results suggest that the neuroprotective effect of prolyl endopeptidase inhibitors is mediated by neuropeptides such as [Arg8]vasopressin and TRH, and indicate the involvement of vasopressin receptors in the neuroprotective effect of vasopressin-(4-9) and prolyl endopeptidase inhibitors. Copyright (C) 1999 Elsevier Science B.V.
AB - We investigated the effects of the prolyl endopeptidase inhibitors 1-[1-(Benzyloxycarbonyl)-l-prolyl]prolinal (Z-Pro-Prolinal) and N-benzyloxycarbonyl-thioprolyl-thioprolinal-dimethylacetal (ZTTA) on delayed neuronal death induced by four-vessel-occlusion transient ischemia in rats. We also examined the effects of [pGlu4, Cyt6, Arg8]vasopressin (vasopressin-(4-9)) and thyrotropin-releasing hormone (TRH) on the delayed neuronal death. Furthermore, we investigated the role of vasopressin receptors in the effects of vasopressin and prolyl endopeptidase inhibitors. Z-Pro-Prolinal, vasopressin-(4-9) and TRH protected pyramidal cells in the CA1 subfield of the rat hippocampus from delayed neuronal death after 10-min ischemia. The effect of vasopressin-(4-9) was abolished by vasopressin receptor antagonists. The effect of Z-Pro-Prolinal was also abrogated by the antagonists. These results suggest that the neuroprotective effect of prolyl endopeptidase inhibitors is mediated by neuropeptides such as [Arg8]vasopressin and TRH, and indicate the involvement of vasopressin receptors in the neuroprotective effect of vasopressin-(4-9) and prolyl endopeptidase inhibitors. Copyright (C) 1999 Elsevier Science B.V.
KW - Ischemia
KW - Neuronal death, delayed
KW - Prolyl endopeptidase inhibitor
KW - Pyramidal cell
KW - Vasopressin-(4-9)
KW - Z-Pro-Prolinal
KW - ZTTA (N-benzyloxycarbonyl-thioprolyl-thioprolinal-dimethylacetal)
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U2 - 10.1016/S0014-2999(99)00185-5
DO - 10.1016/S0014-2999(99)00185-5
M3 - Article
C2 - 10395093
AN - SCOPUS:0033047716
SN - 0014-2999
VL - 372
SP - 135
EP - 142
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -