TY - JOUR
T1 - Effects of timing of acute and consecutive catechin ingestion on postprandial glucose metabolism in mice and humans
AU - Takahashi, Masaki
AU - Ozaki, Mamiho
AU - Tsubosaka, Miku
AU - Kim, Hyeon Ki
AU - Sasaki, Hiroyuki
AU - Matsui, Yuji
AU - Hibi, Masanobu
AU - Osaki, Noriko
AU - Miyashita, Masashi
AU - Shibata, Shigenobu
N1 - Funding Information:
Funding: This work was supported by the Japan Society for the Promotion of Science (KAKENHI Grant Number 19H01089 and 19K21597 to S.S.) and the Kao Research Council for the Study of Healthcare Science (M.T. (Masaki Takahashi)).
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/2
Y1 - 2020/2
N2 - We examined the effects of the timing of acute and consecutive epigallocatechin gallate (EGCG) and catechin-rich green tea ingestion on postprandial glucose in mice and human adults. In mouse experiments, we compared the effects of EGCG administration early (morning) and late (evening) in the active period on postprandial glucose. In human experiments, participants were randomly assigned to the morning-placebo (MP, n = 10), morning-green tea (MGT, n = 10), evening-placebo (EP, n = 9), and evening-green tea (EGT, n = 9) groups, and consumed either catechin-rich green tea or a placebo beverage for 1 week. At baseline and after 1 week, participants consumed their designated beverages with breakfast (MP and MGT) or supper (EP and EGT). Venous blood samples were collected in the fasted state and 30, 60, 120, and 180 min after each meal. Consecutive administration of EGCG in the evening, but not in the morning, reduced postprandial glucose at 30 (p = 0.006) and 60 (p = 0.037) min in the evening trials in mice. In humans, ingestion of catechin-rich green tea in the evening decreased postprandial glucose (three-factor analysis of variance, p < 0.05). Thus, catechin intake in the evening more effectively suppressed elevation of postprandial glucose.
AB - We examined the effects of the timing of acute and consecutive epigallocatechin gallate (EGCG) and catechin-rich green tea ingestion on postprandial glucose in mice and human adults. In mouse experiments, we compared the effects of EGCG administration early (morning) and late (evening) in the active period on postprandial glucose. In human experiments, participants were randomly assigned to the morning-placebo (MP, n = 10), morning-green tea (MGT, n = 10), evening-placebo (EP, n = 9), and evening-green tea (EGT, n = 9) groups, and consumed either catechin-rich green tea or a placebo beverage for 1 week. At baseline and after 1 week, participants consumed their designated beverages with breakfast (MP and MGT) or supper (EP and EGT). Venous blood samples were collected in the fasted state and 30, 60, 120, and 180 min after each meal. Consecutive administration of EGCG in the evening, but not in the morning, reduced postprandial glucose at 30 (p = 0.006) and 60 (p = 0.037) min in the evening trials in mice. In humans, ingestion of catechin-rich green tea in the evening decreased postprandial glucose (three-factor analysis of variance, p < 0.05). Thus, catechin intake in the evening more effectively suppressed elevation of postprandial glucose.
KW - Epigallocatechin gallate
KW - Glucose metabolism
KW - Green tea
KW - Insulin
KW - Timing
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U2 - 10.3390/nu12020565
DO - 10.3390/nu12020565
M3 - Article
C2 - 32098219
AN - SCOPUS:85079845849
SN - 2072-6643
VL - 12
JO - Nutrients
JF - Nutrients
IS - 2
M1 - 565
ER -