Eight new cytotoxic metabolites closely related to onnamide A from two marine sponges of the genus Theonella

Shigeki Matsunaga; Nobuhiro Fusetani; Youichi Nakao

doi:10.1016/S0040-4020(01)86585-6

Eight new cytotoxic metabolites closely related to onnamide A from two marine sponges of the genus Theonella

Shigeki Matsunaga^*, Nobuhiro Fusetani, Youichi Nakao

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Abstract

New cytotoxic compounds 1-7 were isolated along with onnamide A (9) from a marine sponge Theonella sp. collected at Hachijo Island, whereas another Theonella sponge yielded 8. The structures of these compounds were determined by interpretation of the NMR spectral data as well as by comparison of spectral data with those of 9. Six compounds (1-6) were highly cytotoxic against the P388 cell line.

Original language	English
Pages (from-to)	8369-8376
Number of pages	8
Journal	Tetrahedron
Volume	48
Issue number	39
DOIs	https://doi.org/10.1016/S0040-4020(01)86585-6
Publication status	Published - 1992 Sept 25
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0040-4020(01)86585-6

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title = "Eight new cytotoxic metabolites closely related to onnamide A from two marine sponges of the genus Theonella",

abstract = "New cytotoxic compounds 1-7 were isolated along with onnamide A (9) from a marine sponge Theonella sp. collected at Hachijo Island, whereas another Theonella sponge yielded 8. The structures of these compounds were determined by interpretation of the NMR spectral data as well as by comparison of spectral data with those of 9. Six compounds (1-6) were highly cytotoxic against the P388 cell line.",

author = "Shigeki Matsunaga and Nobuhiro Fusetani and Youichi Nakao",

note = "Funding Information: Acknowledgment. We thank Professor P. J. Scheuer of the University of Hawaii for reading the manuscript. We are also indebted to C.Nohara, Central Research Laboratories, Yamanouchi Pharmaceutical Co.,Ltd., for cytotoxicity tests. This work was partially supported by a Grant-in Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan and by the Fujisawa Foundation.",

year = "1992",

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doi = "10.1016/S0040-4020(01)86585-6",

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T1 - Eight new cytotoxic metabolites closely related to onnamide A from two marine sponges of the genus Theonella

AU - Matsunaga, Shigeki

AU - Fusetani, Nobuhiro

AU - Nakao, Youichi

N1 - Funding Information: Acknowledgment. We thank Professor P. J. Scheuer of the University of Hawaii for reading the manuscript. We are also indebted to C.Nohara, Central Research Laboratories, Yamanouchi Pharmaceutical Co.,Ltd., for cytotoxicity tests. This work was partially supported by a Grant-in Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan and by the Fujisawa Foundation.

PY - 1992/9/25

Y1 - 1992/9/25

N2 - New cytotoxic compounds 1-7 were isolated along with onnamide A (9) from a marine sponge Theonella sp. collected at Hachijo Island, whereas another Theonella sponge yielded 8. The structures of these compounds were determined by interpretation of the NMR spectral data as well as by comparison of spectral data with those of 9. Six compounds (1-6) were highly cytotoxic against the P388 cell line.

AB - New cytotoxic compounds 1-7 were isolated along with onnamide A (9) from a marine sponge Theonella sp. collected at Hachijo Island, whereas another Theonella sponge yielded 8. The structures of these compounds were determined by interpretation of the NMR spectral data as well as by comparison of spectral data with those of 9. Six compounds (1-6) were highly cytotoxic against the P388 cell line.

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DO - 10.1016/S0040-4020(01)86585-6

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JO - Tetrahedron

JF - Tetrahedron

IS - 39

ER -

Eight new cytotoxic metabolites closely related to onnamide A from two marine sponges of the genus Theonella

Abstract

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UN SDGs

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